Gene
rest
- ID
- ZDB-GENE-080415-1
- Name
- RE1-silencing transcription factor
- Symbol
- rest Nomenclature History
- Previous Names
-
- Nrsf (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have metal ion binding activity and nucleic acid binding activity. Involved in several processes, including locomotory behavior; negative regulation of smoothened signaling pathway; and nervous system development. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Is expressed in ectoderm; endoderm; fin; head mesenchyme; and nervous system. Orthologous to human REST (RE1 silencing transcription factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 27 | Alliance | Deafness, autosomal dominant 27 | 612431 |
| gingival fibromatosis 5 | Alliance | Fibromatosis, gingival, 5 | 617626 |
| {Wilms tumor 6, susceptibility to} | 616806 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger and ubiquitin peptidase domain-containing protein | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
|
UniProtKB:A0A0R4IKA2
|
854 |
Interactions and Pathways
No data available
Plasmids
No data available