Gene

rest

ID

ZDB-GENE-080415-1

Name

RE1-silencing transcription factor

Symbol

rest Nomenclature History

Previous Names

Nrsf (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity and nucleic acid binding activity. Involved in several processes, including locomotory behavior; negative regulation of smoothened signaling pathway; and nervous system development. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Is expressed in ectoderm; endoderm; fin; head mesenchyme; and nervous system. Orthologous to human REST (RE1 silencing transcription factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 22 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rest Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 27	Alliance	Deafness, autosomal dominant 27	612431
gingival fibromatosis 5	Alliance	Fibromatosis, gingival, 5	617626
		{Wilms tumor 6, susceptibility to}	616806

Associated With rest Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Family	IPR050688	Zinc finger and ubiquitin peptidase domain-containing protein
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily