Gene
lifrb
- ID
- ZDB-GENE-080107-2
- Name
- LIF receptor subunit alpha b
- Symbol
- lifrb Nomenclature History
- Previous Names
-
- si:dkey-120e24.3
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have cytokine binding activity and cytokine receptor activity. Predicted to localize to external side of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in osteochondrodysplasia and primary cutaneous amyloidosis. Is expressed in several structures, including immune system; liver; nervous system; notochord; and otic vesicle. Orthologous to several human genes including LIFR (LIF receptor subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hanington et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Stuve-Wiedemann syndrome/Schwartz-Jampel type 2 syndrome | 601559 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003529 | Long hematopoietin receptor, Gp130 family 2, conserved site |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR040817 | Leukemia inhibitory factor receptor, D2 domain |
| Family | IPR050379 | Type I Cytokine Receptor |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Leukemia inhibitory factor receptor, D2 domain | Long hematopoietin receptor, Gp130 family 2, conserved site | Type I Cytokine Receptor |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1Q5F5
|
960 | ||||||
|
UniProtKB:A8WH83
|
956 |
Interactions and Pathways
No data available
Plasmids
No data available