Gene

chata

ID

ZDB-GENE-080102-2

Name

choline O-acetyltransferase a

Symbol

chata Nomenclature History

Previous Names

baj
chat
unm tk64
unm_tk64

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable choline O-acetyltransferase activity. Involved in locomotory behavior. Predicted to be active in cytoplasm and neuron projection. Is expressed in brain; neurons; post-vent region; spinal cord; and spinal cord neural tube. Used to study congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Orthologous to human CHAT (choline O-acetyltransferase).

Genome Resources

Note

Yokogawa et al. (2007) identified the chat gene with Ensembl ENSDARG00000015854 on Chr. 13.

Comparative Information

Expression

All Expression Data

24 figures from 16 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With chata Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital myasthenic syndrome 6	Alliance	Myasthenic syndrome, congenital, 6, presynaptic	254210

Associated With chata Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital myasthenic syndrome	chata^tk64/tk64 (AB)	standard conditions	Joshi et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR039551	Choline/carnitine acyltransferase domain
Family	IPR000542	Acyltransferase ChoActase/COT/CPT
Homologous_superfamily	IPR023213	Chloramphenicol acetyltransferase-like domain superfamily
Homologous_superfamily	IPR042231	Choline/Carnitine o-acyltransferase, domain 2