Gene
nkd2a
- ID
- ZDB-GENE-071130-1
- Name
- NKD inhibitor of WNT signaling pathway 2a
- Symbol
- nkd2a Nomenclature History
- Previous Names
-
- nkd2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including Kupffer's vesicle development; Spemann organizer formation; and negative regulation of canonical Wnt signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in blastoderm; blastodisc; brain; and tail bud. Orthologous to human NKD2 (NKD inhibitor of WNT signaling pathway 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Protein naked cuticle-like |
|---|---|---|---|---|---|
|
UniProtKB:F1QI44
|
|||||
|
UniProtKB:A4ZNR4
|
409 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-377N8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001098197 (1) | 1340 nt | ||
| Genomic | GenBank:CU463028 | 114212 nt | ||
| Polypeptide | UniProtKB:A4ZNR4 (1) | 409 aa |
- Song, G., Han, M., Li, Z., Gan, X., Chen, X., Yang, J., Dong, S., Yan, M., Wan, J., Wang, Y., Huang, Z., Yin, Z., Zheng, F. (2018) Deletion of Pr72 causes cardiac developmental defects in Zebrafish. PLoS One. 13:e0206883
- Marsden, A.N., Derry, S.W., Schneider, I., Scott, C.A., Westfall, T.A., Brastrom, L.K., Shea, M., Dawson, D.V., Slusarski, D.C. (2017) The Nkd EF-Hand Domain Modulates Divergent Wnt Signaling Outputs in Zebrafish. Developmental Biology. 434(1):63-73
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Gao, R., Ma, L.Q., Du, X., Zhang, T.T., Zhao, L., Liu, L., Liu, J.C., Guo, F., Cheng, Z., Huang, H. (2016) Rnf25/AO7 positively regulates wnt signaling via disrupting Nkd1-Axin inhibitory complex independent of its ubiquitin ligase activity. Oncotarget. 7(17):23850-9
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hu, T., Li, C., Cao, Z., Van Raay, T.J., Smith, J.G., Willert, K., Solnica-Krezel, L., and Coffey, R.J. (2010) Myristoylated naked2 antagonizes WNT-{beta}-catenin activity by degrading dishevelled-1 at the plasma membrane. The Journal of biological chemistry. 285(18):13561-13568
- Schneider, I., Schneider, P.N., Derry, S.W., Lin, S., Barton, L.J., Westfall, T., and Slusarski, D.C. (2010) Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Developmental Biology. 348(1):22-33
- Van Raay, T.J., Coffey, R.J., and Solnica-Krezel, L. (2007) Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Developmental Biology. 309(2):151-168
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