Gene
kiss1ra
- ID
- ZDB-GENE-070912-521
- Name
- KISS1 receptor a
- Symbol
- kiss1ra Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables neuropeptide receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in cell surface and cytoplasm. Is expressed in brain; fat cell; head; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in central precocious puberty 1; hypogonadism; and hypogonadotropic hypogonadism 8 with or without anosmia. Orthologous to human KISS1R (KISS1 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| central precocious puberty 1 | Alliance | ?Precocious puberty, central, 1 | 176400 |
| hypogonadotropic hypogonadism 8 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 8 with or without anosmia | 614837 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | KiSS-1 peptide receptor |
|---|---|---|---|---|
|
UniProtKB:B0F101
|
253 | |||
|
UniProtKB:F1R5R4
|
366 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kiss1ra-201
(1)
|
Ensembl | 1,101 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-kiss1ra | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31M5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001105679 (1) | 1101 nt | ||
| Genomic | GenBank:BX649508 (1) | 266518 nt | ||
| Polypeptide | UniProtKB:F1R5R4 (1) | 366 aa |
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Atre, I., Mizrahi, N., Hausken, K., Yom-Din, S., Hurvitz, A., Degani, G., Levavi-Sivan, B. (2020) Molecular characterization of kisspeptin receptors and gene expression analysis during oogenesis in the russian sturgeon (Acipenser gueldenstaedtii). General and comparative endocrinology. 302:113691
- Song, Y., Chen, J., Tao, B., Luo, D., Zhu, Z., Hu, W. (2020) Kisspeptin2 regulates hormone expression in female zebrafish (Danio rerio) pituitary. Molecular and Cellular Endocrinology. 513:110858
- Talya, E., Nilli, Z., Yonatan, Z., Berta, L.S., Matan, G., Yoav, G. (2020) Ectopic over expression of kiss1 may compensate for the loss of kiss2. General and comparative endocrinology. 295:113523
- Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166
- Ogawa, S., Sivalingam, M., Anthonysamy, R., Parhar, I.S. (2019) Distribution of Kiss2 receptor in the brain and its localization in neuroendocrine cells in the zebrafish. Cell and tissue research. 379(2):349-372
- Qiu, W., Fang, M., Liu, J., Fu, C., Zheng, C., Chen, B., Wang, K.J. (2019) In vivo actions of Bisphenol F on the reproductive neuroendocrine system after long-term exposure in zebrafish. The Science of the total environment. 665:995-1002
- Spicer, O.S., Zmora, N., Wong, T.T., Golan, M., Levavi-Sivan, B., Gothilf, Y., Zohar, Y. (2017) The GNIH (Lpxrfa) system's regulation of reproduction in the brain-pituitary axis of the zebrafish (Danio rerio). Biology of reproduction. 96(5):1031-1042
- Khor, Y.M., Soga, T., Parhar, I.S. (2016) Early-Life Stress Changes Expression of GnRH and Kisspeptin Genes and DNA Methylation of GnRH3 Promoter in The Adult Zebrafish Brain. General and comparative endocrinology. 227:84-93
- Muth-Köhne, E., Westphal-Settele, K., Brückner, J., Konradi, S., Schiller, V., Schäfers, C., Teigeler, M., Fenske, M. (2016) Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test. Aquatic toxicology (Amsterdam, Netherlands). 176:116-127
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