Gene
cdkn1a
- ID
- ZDB-GENE-070705-7
- Name
- cyclin dependent kinase inhibitor 1A
- Symbol
- cdkn1a Nomenclature History
- Previous Names
-
- cip1
- p21
- waf1
- si:ch1073-48m5.2
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase inhibitor activity. Acts upstream of or within aorta development; response to X-ray; and skeletal muscle cell differentiation. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; hatching gland; male organism; nervous system; and pectoral fin bud. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 116 figures from 105 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014280Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la014281Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022393Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022394Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028465Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| umo61 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zf3981 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cyclin-dependent kinase inhibitor 1 | Cyclin-dependent kinase inhibitor domain | Cyclin-dependent kinase inhibitor domain superfamily |
|---|---|---|---|---|
|
UniProtKB:A0A8M1RFS1
|
170 | |||
|
UniProtKB:A5WWG2
|
154 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cdkn1a-201
(1)
|
Ensembl | 1,029 nt | ||
| mRNA |
cdkn1a-202
(1)
|
Ensembl | 834 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| AB1-cdkn1a | polyclonal | Rabbit |
|
Cosmo Bio Co. LTD.
|
1 |
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Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(cdkn1a:GFP) |
|
| 1 | Morsli et al., 2023 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-48M5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128420 (1) | 2173 nt | ||
| Genomic | GenBank:CU062631 (2) | 27912 nt | ||
| Polypeptide | UniProtKB:A0A8M1RFS1 (1) | 170 aa |
- Lai, S., Shiraishi, H., Sebastian, W.A., Shimizu, N., Umeda, R., Ikeuchi, M., Kiyota, K., Takeno, T., Miyazaki, S., Yano, S., Shimada, T., Yoshimura, A., Hanada, R., Hanada, T. (2024) Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Communications biology. 7:654654
- Prykhozhij, S.V., Ban, K., Brown, Z.L., Kobar, K., Wajnberg, G., Fuller, C., Chacko, S., Lacroix, J., Crapoulet, N., Midgen, C., Shlien, A., Malkin, D., Berman, J.N. (2024) miR-34a is a tumor suppressor in zebrafish and its expression levels impact metabolism, hematopoiesis and DNA damage. PLoS Genetics. 20:e1011290e1011290
- Song, W., Xia, X., Fan, Y., Zhang, B., Chen, X. (2024) Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia. International Journal of Molecular Sciences. 25(9):
- Weiss, A., D'Amata, C., Pearson, B.J., Hayes, M.N. (2024) A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo. eLIFE. 13:
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Zhang, P., Cao, J., Liang, X., Su, Z., Zhang, B., Wang, Z., Xie, J., Chen, G., Chen, X., Zhang, J., Feng, Y., Xu, Q., Song, J., Hong, A., Chen, X., Zhang, Y. (2024) Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis. Acta biochimica et biophysica Sinica. 56(4):621-633
- Ajouaou, Y., Magnani, E., Madakashira, B., Jenkins, E., Sadler, K.C. (2023) atm Mutation and Oxidative Stress Enhance the Pre-Cancerous Effects of UHRF1 Overexpression in Zebrafish Livers. Cancers. 15(8):
- Amin, A., Morello, M., Petrara, M.R., Rizzo, B., Argenton, F., De Rossi, A., Giunco, S. (2023) Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach. Cancers. 15(10):
- Boos, A., Gahr, B.M., Park, D.D., Braun, V., Bühler, A., Rottbauer, W., Just, S. (2023) Hdac1-deficiency affects the cell cycle axis Cdc25-Cdk1 causing impaired G2/M phase progression and reduced cardiomyocyte proliferation in zebrafish. Biochemical and Biophysical Research Communications. 665:9810698-106
- Chen, D.D., Liu, B., Wang, Y., Jiang, M., Shang, G., Xue, M., Jia, X., Lang, Y., Zhou, G., Zhang, F., Peng, X., Hu, Y. (2023) The downregulation of HSP90-controlled CRALBP expression is associated with age-related vision attenuation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22832e22832
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