Gene
cdkn1a
- ID
- ZDB-GENE-070705-7
- Name
- cyclin dependent kinase inhibitor 1A
- Symbol
- cdkn1a Nomenclature History
- Previous Names
-
- cip1
- p21
- waf1
- si:ch1073-48m5.2
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase inhibitor activity. Acts upstream of or within aorta development; response to X-ray; and skeletal muscle cell differentiation. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; hatching gland; male organism; nervous system; and pectoral fin bud. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 116 figures from 105 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cyclin-dependent kinase inhibitor 1 | Cyclin-dependent kinase inhibitor domain | Cyclin-dependent kinase inhibitor domain superfamily |
|---|---|---|---|---|
|
UniProtKB:A0A8M1RFS1
|
170 | |||
|
UniProtKB:A5WWG2
|
154 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cdkn1a-201
(1)
|
Ensembl | 1,029 nt | ||
| mRNA |
cdkn1a-202
(1)
|
Ensembl | 834 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| AB1-cdkn1a | polyclonal | Rabbit |
|
Cosmo Bio Co. LTD.
|
1 |
Plasmids