Gene
myo1ca
- ID
- ZDB-GENE-070705-190
- Name
- myosin Ic, paralog a
- Symbol
- myo1ca Nomenclature History
- Previous Names
-
- si:ch211-69i14.4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within glomerulus development. Predicted to be located in cytoplasmic vesicle; ruffle; and stereocilium membrane. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and vesicle. Is expressed in brain; gut; myotome; notochord; and pronephric glomerulus. Orthologous to human MYO1C (myosin IC).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Arif et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Arif et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16308 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20485 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25307 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa30862 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33658 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38492 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40512 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45215 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 8 of 8
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR010926 | Class I myosin tail homology domain |
| Domain | IPR036072 | Class I myosin, motor domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
1 - 5 of 5
Domain Details Per Protein
| Protein | Length | Class I myosin, motor domain | Class I myosin tail homology domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
|
UniProtKB:A5PF48
|
1026 | |||||
|
UniProtKB:A0A8M2BCM9
|
1029 | |||||
|
UniProtKB:A0A0H2UKD8
|
1045 |
1 - 3 of 3
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
myo1ca-201
(1)
|
Ensembl | 3,823 nt | ||
| mRNA |
myo1ca-202
(1)
|
Ensembl | 3,653 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-69I14 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001431131 (1) | 3939 nt | ||
| Genomic | GenBank:AL935065 (1) | 99807 nt | ||
| Polypeptide | UniProtKB:A0A0H2UKD8 (1) | 1045 aa |
- Comparative Orthology
- Alliance
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Bayat, N., Lopes, V.R., Schölermann, J., Jensen, L.D., Cristobal, S. (2015) Vascular toxicity of ultra-small TiO2 nanoparticles and single walled carbon nanotubes in vitro and in vivo. Biomaterials. 63:1-13
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Arif, E., Kumari, B., Wagner, M.C., Zhou, W., Holzman, L.B., and Nihalani, D. (2013) Myo1c is an unconventional myosin required for zebrafish glomerular development. Kidney International. 84(6):1154-65
1 - 4 of 4
Show