Gene
ppm1e
- ID
- ZDB-GENE-070326-2
- Name
- protein phosphatase, Mg2+/Mn2+ dependent, 1E
- Symbol
- ppm1e Nomenclature History
- Previous Names
-
- camkp-n (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable kinase activity; metal ion binding activity; and protein serine/threonine phosphatase activity. Acts upstream of or within dephosphorylation. Located in nucleus. Is expressed in central nervous system. Orthologous to human PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Nimura et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Nimura et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa21762 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | PPM-type phosphatase, divalent cation binding | PPM-type phosphatase-like domain | PPM-type phosphatase-like domain superfamily | Protein phosphatase 2C |
|---|---|---|---|---|---|
|
UniProtKB:Q53VM5
|
633 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-197B6 | ZFIN Curated Data | |
| Contained in | BAC | CH211-251D10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-202P3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193643 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020518 (1) | 2028 nt | ||
| Genomic | GenBank:AL935324 | 197730 nt | ||
| Polypeptide | UniProtKB:Q53VM5 (1) | 633 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Emerson, S.E., St Clair, R.M., Waldron, A.L., Bruno, S.R., Duong, A., Driscoll, H.E., Ballif, B.A., McFarlane, S., Ebert, A.M. (2017) Identification of target genes downstream of Semaphorin6A/PlexinA2 signaling in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(7):539-549
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Onouchi, T., Sueyoshi, N., Ishida, A., and Kameshita, I. (2012) Phosphorylation and activation of nuclear Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP-N/PPM1E) by Ca(2+)/calmodulin-dependent protein kinase I (CaMKI). Biochemical and Biophysical Research Communications. 422(4):703-709
- Sueyoshi, N., Nimura, T., Onouchi, T., Baba, H., Takenaka, S., Ishida, A., and Kameshita, I. (2012) Functional processing of nuclear Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP-N): Evidence for a critical role of proteolytic processing in the regulation of its catalytic activity, subcellular localization and substrate targeting in vivo. Archives of biochemistry and biophysics. 517(1):43-52
- Nimura, T., Sugiyama, Y., Sueyoshi, N., Shigeri, Y., Ishida, A., and Kameshita, I. (2010) A minimum size homologue of Ca2+/calmodulin-dependent protein kinase IV naturally occurring in zebrafish. Journal of biochemistry. 147(6):857-865
- Sueyoshi, N., Nimura, T., Ishida, A., Taniguchi, T., Yoshimura, Y., Ito, M., Shigeri, Y., and Kameshita, I. (2009) Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP) is indispensable for normal embryogenesis in zebrafish, Danio rerio. Archives of biochemistry and biophysics. 488(1):48-59
- Nimura, T., Sueyoshi, N., Ishida, A., Yoshimura, Y., Ito, M., Tokumitsu, H., Shigeri, Y., Nozaki, N., and Kameshita, I. (2007) Knockdown of nuclear Ca(2+)/calmodulin-dependent protein kinase phosphatase causes developmental abnormalities in zebrafish. Archives of biochemistry and biophysics. 457(2):205-216
- Sueyoshi, N., Takao, T., Nimura, T., Sugiyama, Y., Numano, T., Shigeri, Y., Taniguchi, T., Kameshita, I., and Ishida, A. (2007) Inhibitors of the Ca(2+)/calmodulin-dependent protein kinase phosphatase family (CaMKP and CaMKP-N). Biochemical and Biophysical Research Communications. 363(3):715-721
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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