Gene

plod2

ID

ZDB-GENE-070326-1

Name

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

Symbol

plod2 Nomenclature History

Previous Names

lh2 (1)
zgc:101868

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Exhibits procollagen-lysine 5-dioxygenase activity. Involved in several processes, including collagen biosynthetic process; collagen fibril organization; and skeletal muscle fiber development. Predicted to localize to endoplasmic reticulum. Used to study Bruck syndrome. Is expressed in several structures, including fin; hypochord; intestine; shield; and skeletal system. Orthologous to human PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plod2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Bruck syndrome	Alliance	Bruck syndrome 2	609220

Associated With plod2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Bruck syndrome	plod2^{sa1768/sa1768}	standard conditions	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001006	Procollagen-lysine 5-dioxygenase, conserved site
Domain	IPR005123	Oxoglutarate/iron-dependent dioxygenase domain
Domain	IPR006620	Prolyl 4-hydroxylase, alpha subunit
Domain	IPR044861	Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain
Family	IPR050757	Collagen-modifying Glycosyltransferase 25
Homologous_superfamily	IPR029044	Nucleotide-diphospho-sugar transferases

Domain Details Per Protein

Protein	Length	Collagen-modifying Glycosyltransferase 25	Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain	Nucleotide-diphospho-sugar transferases	Oxoglutarate/iron-dependent dioxygenase domain	Procollagen-lysine 5-dioxygenase, conserved site	Prolyl 4-hydroxylase, alpha subunit
UniProtKB:A4U7F8 InterPro	733
UniProtKB:A4U7F9 InterPro	754

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	plod2-201 (1) Ensembl	Ensembl	3,370 nt	Select Tool
mRNA	plod2-202 (1) Ensembl	Ensembl	3,307 nt	Select Tool
ncRNA	plod2-003 (1) Ensembl	Ensembl	1,190 nt	Select Tool
ncRNA	plod2-004 (1) Ensembl	Ensembl	645 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-plod2	polyclonal	plod2	IgG	Rabbit	WB	Proteintech	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations