Gene
csf1b
- ID
- ZDB-GENE-061215-106
- Name
- colony stimulating factor 1b (macrophage)
- Symbol
- csf1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in digestive system; integument; and iridophore. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wu et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hkz10 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la011093Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| re06 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| re07 | Allele with one delins | Unknown | Unknown | CRISPR | |
| t34ui | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-csf1b | (2) | |
| CRISPR2-csf1b | (3) | |
| CRISPR3-csf1b | Hason et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Four-helical cytokine-like, core | Macrophage colony stimulating factor-1 |
|---|---|---|---|
|
UniProtKB:A1A5Z5
|
255 | ||
|
UniProtKB:B0UYR0
|
284 |
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Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-14F20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158436 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080076 (1) | 1456 nt | ||
| Genomic | GenBank:CR550308 (2) | 137439 nt | ||
| Polypeptide | UniProtKB:B0UYR0 (1) | 284 aa |
- Sobah, M.L., Liongue, C., Ward, A.C. (2024) Stat3 regulates developmental hematopoiesis and impacts myeloid cell function via canonical and non-canonical modalities. Journal of Innate Immunity. 16(1):262-282
- Bravo, P., Liu, Y., Draper, B.W., Marlow, F.L. (2023) Macrophage activation drives ovarian failure and masculinization in zebrafish. Science advances. 9:eadg7488eadg7488
- Dai, Y., Wu, S., Cao, C., Xue, R., Luo, X., Wen, Z., Xu, J. (2022) Csf1rb regulates definitive hematopoiesis in zebrafish. Development (Cambridge, England). 149(16)
- Deng, Y., Wang, H., Liu, X., Yuan, H., Xu, J., de Thé, H., Zhou, J., Zhu, J. (2022) Zbtb14 regulates monocyte and macrophage development through inhibiting pu.1 expression in zebrafish. eLIFE. 11:
- Hason, M., Mikulasova, T., Machonova, O., Pombinho, A.R., van Ham, T.J., Irion, U., Nüsslein-Volhard, C., Bartunek, P., Svoboda, O. (2022) M-CSFR/CSF1R signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligands. Blood advances. 6(5):1474-1488
- Zhao, S., Zhang, A., Zhu, H., Wen, Z. (2022) The ETS transcription factor Spi2 regulates hematopoietic cell development in zebrafish. Development (Cambridge, England). 149(19)
- Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264
- Kuil, L.E., Oosterhof, N., Ferrero, G., Mikulášová, T., Hason, M., Dekker, J., Rovira, M., van der Linde, H.C., van Strien, P.M., de Pater, E., Schaaf, G., Bindels, E.M., Wittamer, V., van Ham, T.J. (2020) Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. eLIFE. 9:
- Peng, L., Wang, C., Li, P., Cheng, B., Hu, Y., Cheng, Y., Zheng, Q. (2020) Evaluation of hypopigmentation in embryonic zebrafish induced by emerging disinfection byproduct, 3, 5-di-I-tyrosylalanine. Aquatic toxicology (Amsterdam, Netherlands). 225:105525
- Yang, L., Jiménez, J.A., Earley, A.M., Hamlin, V., Kwon, V., Dixon, C.T., Shiau, C.E. (2020) Drainage of inflammatory macromolecules from brain to periphery targets the liver for macrophage infiltration. eLIFE. 9:
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