Gene
nod2
- ID
- ZDB-GENE-061108-4
- Name
- nucleotide-binding oligomerization domain containing 2
- Symbol
- nod2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have CARD domain binding activity. Involved in defense response to bacterium; defense response to virus; and regulation of transcription, DNA-templated. Localizes to cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Blau syndrome; autoimmune hypersensitivity disease (multiple); intestinal disease (multiple); and lung disease (multiple). Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and unfertilized egg. Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Nayar et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Blau syndrome | Alliance | Blau syndrome | 186580 |
| inflammatory bowel disease 1 | Alliance | {Inflammatory bowel disease 1, Crohn disease} | 266600 |
| {Yao syndrome} | 617321 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001315 | CARD domain |
| Domain | IPR007111 | NACHT nucleoside triphosphatase |
| Domain | IPR041075 | NOD1/2, winged helix domain |
| Domain | IPR041267 | NACHT, LRR and PYD domains-containing protein, helical domain HD2 |
| Family | IPR051261 | NOD-like receptor (NLR) |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
Domain Details Per Protein
| Protein | Length | CARD domain | Death-like domain superfamily | Leucine-rich repeat | Leucine-rich repeat domain superfamily | NACHT, LRR and PYD domains-containing protein, helical domain HD2 | NACHT nucleoside triphosphatase | NOD1/2, winged helix domain | NOD-like receptor (NLR) | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F8W3K2
|
980 |
Interactions and Pathways
No data available
Plasmids
No data available