Gene

ywhag2

ID

ZDB-GENE-061023-2

Name

3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2

Symbol

ywhag2 Nomenclature History

Previous Names

ywhagl

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable protein kinase C binding activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 56. Orthologous to human YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Cao et al., 2018

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ywhag2 Human Ortholog

No data available

Associated With ywhag2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023409	14-3-3 protein, conserved site
Domain	IPR023410	14-3-3 domain
Family	IPR000308	14-3-3 protein
Homologous_superfamily	IPR036815	14-3-3 domain superfamily

Domain Details Per Protein

Protein	Length	14-3-3 domain	14-3-3 domain superfamily	14-3-3 protein	14-3-3 protein, conserved site
UniProtKB:E7F354 InterPro	247

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ywhag2-201 (1) Ensembl	Ensembl		2,518 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: Analysis of this gene family suggests that there are two orthologs, which are being named 1 and 2 due to a lack of synteny. The sequence used to populate this gene, BI476554, was via author corrrespondance.

Citations