Gene
pals1b
- ID
- ZDB-GENE-060531-2
- Name
- protein associated with LIN7 1, MAGUK p55 family member b
- Symbol
- pals1b Nomenclature History
- Previous Names
-
- im:7140055
- mpp5b
- ponli (1)
- sb:eu974
- si:ch211-105d18.1
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; morphogenesis of an epithelium; and protein localization to plasma membrane. Predicted to be located in bicellular tight junction and membrane. Predicted to be active in adherens junction and plasma membrane. Is expressed in eye; retinal cone cell; and retinal photoreceptor layer. Orthologous to human PALS1 (protein associated with LIN7 1, MAGUK p55 family member).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021726Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021727Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| zju204 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pals1b | Zebrafish Nomenclature Committee | |
| MO1-pals1b | N/A | (3) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | L27 domain | L27 domain, C-terminal | L27 domain superfamily | L27-N | Membrane-associated guanylate kinase | MPP5, SH3 domain | PDZ domain | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:D3X469
|
639 | ||||||||||||||
|
UniProtKB:A8DZ97
|
363 | ||||||||||||||
|
UniProtKB:A0A8M3B4D4
|
512 | ||||||||||||||
|
UniProtKB:A0A8M9PP48
|
403 | ||||||||||||||
|
UniProtKB:A0A8M3AL41
|
537 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pals1b | polyclonal | Rabbit |
|
3 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1.9pals1b:pals1b-GFP) |
|
|
| 4 | Fang et al., 2017 |
| Tg(-6.1pals1b:pals1b-HA-mCherry) |
|
| 1 | Fang et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-105D18 | ZFIN Curated Data | |
| Encodes | EST | eu974 | Thisse et al., 2005 | |
| Encodes | EST | IMAGE:7140055 | Thisse et al., 2004 | |
| interacts with | Enhancer | en.mpp5b_enh1 | Fang et al., 2017 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423432 (1) | 4254 nt | ||
| Genomic | GenBank:AL928824 (1) | 189742 nt | ||
| Polypeptide | UniProtKB:D3X469 (1) | 639 aa |
- Hao, Y., Zhou, Y., Yu, Y., Zheng, M., Weng, K., Kou, Z., Liang, J., Zhang, Q., Tang, X., Xu, P., Link, B.A., Yao, K., Zou, J. (2020) Interplay of MPP5a with Rab11 synergistically builds epithelial apical polarity and zonula adherens. Development (Cambridge, England). 147(22):
- Fang, W., Guo, C., Wei, X. (2017) Rainbow Enhancers Regulate Restrictive Transcription in Teleost Green, Red, and Blue Cones.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(11):2834-2848
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Zou, J., Wen, Y., Yang, X., and Wei, X. (2013) Spatial-temporal expressions of Crumbs and Nagie oko and their interdependence in zebrafish central nervous system during early development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 31(8):770-782
- Zou, J., Yang, X., and Wei, X. (2010) Restricted localization of ponli, a novel zebrafish MAGUK-family protein, to the inner segment interface areas between green, red, and blue cones. Investigative ophthalmology & visual science. 51(3):1738-1746
- Yang, X., Zou, J., Hyde, D.R., Davidson, L.A., and Wei, X. (2009) Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(37):11426-11440
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Wu, V.M., Yu, M.H., Paik, R., Banerjee, S., Liang, Z., Paul, S.M., Bhat, M.A., and Beitel, G.J. (2007) Drosophila Varicose, a member of a new subgroup of basolateral MAGUKs, is required for septate junctions and tracheal morphogenesis. Development (Cambridge, England). 134(5):999-1009
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