Gene

fras1

ID

ZDB-GENE-060526-68

Name

Fraser extracellular matrix complex subunit 1

Symbol

fras1 Nomenclature History

Previous Names

id:ibd5080
pif (1)
pinfin (1)
si:ch211-191a6.5
wu:fc10b09

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Involved in several processes, including basement membrane organization; embryonic viscerocranium morphogenesis; and epithelial structure maintenance. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Is expressed in several structures, including epithelium; mesoderm; nervous system; pharyngeal arch; and trunk. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

28 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7159429 (21 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fras1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Fraser syndrome 1	Alliance	Fraser syndrome 1	219000

Associated With fras1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR001007	VWFC domain
Domain	IPR003644	Na-Ca exchanger/integrin-beta4
Family	IPR051561	FRAS1-related extracellular matrix
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR038081	CalX-like domain superfamily
Repeat	IPR006212	Furin-like repeat
Repeat	IPR039005	CSPG repeat

Domain Details Per Protein

Protein	Length	CalX-like domain superfamily	CSPG repeat	EGF-like domain	FRAS1-related extracellular matrix	Furin-like repeat	Growth factor receptor cysteine-rich domain superfamily	Na-Ca exchanger/integrin-beta4	VWFC domain
UniProtKB:F1Q633 InterPro	3970
UniProtKB:A0A8M9Q8W1 InterPro	3992
UniProtKB:A0A8M3AZT2 InterPro	4002
UniProtKB:A0A0R4IQJ3 InterPro	4003

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fras1-201 (1) Ensembl	Ensembl	11,913 nt	Select Tool ZFIN BLAST
mRNA	fras1-202 (1) Ensembl	Ensembl	11,970 nt	Select Tool ZFIN BLAST
mRNA	fras1-203 (1) Ensembl	Ensembl	12,999 nt	Select Tool ZFIN BLAST
mRNA	fras1-205 (1) Ensembl	Ensembl	12,268 nt	Select Tool ZFIN BLAST
ncRNA	fras1-002 (1) Ensembl	Ensembl	505 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-fras1	polyclonal	fras1		Rabbit	IHC		5

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations