Gene
fras1
- ID
- ZDB-GENE-060526-68
- Name
- Fraser extracellular matrix complex subunit 1
- Symbol
- fras1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Involved in several processes, including basement membrane organization; embryonic viscerocranium morphogenesis; and epithelial structure maintenance. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Is expressed in several structures, including epithelium; mesoderm; nervous system; pharyngeal arch; and trunk. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159429 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Fraser syndrome 1 | Alliance | Fraser syndrome 1 | 219000 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000742 | EGF-like domain |
Domain | IPR001007 | VWFC domain |
Domain | IPR003644 | Na-Ca exchanger/integrin-beta4 |
Family | IPR051561 | FRAS1-related extracellular matrix |
Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
Homologous_superfamily | IPR038081 | CalX-like domain superfamily |
Repeat | IPR006212 | Furin-like repeat |
Repeat | IPR039005 | CSPG repeat |
Domain Details Per Protein
Protein | Length | CalX-like domain superfamily | CSPG repeat | EGF-like domain | FRAS1-related extracellular matrix | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Na-Ca exchanger/integrin-beta4 | VWFC domain |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:F1Q633
|
3970 | ||||||||
UniProtKB:A0A8M9Q8W1
|
3992 | ||||||||
UniProtKB:A0A8M3AZT2
|
4002 | ||||||||
UniProtKB:A0A0R4IQJ3
|
4003 |
Interactions and Pathways
No data available
Plasmids
No data available