Gene
tbk1
- ID
- ZDB-GENE-060512-359
- Name
- TANK-binding kinase 1
- Symbol
- tbk1 Nomenclature History
- Previous Names
-
- wu:fk70c05
- zgc:136548 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within negative regulation of type I interferon production. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4. Orthologous to human TBK1 (TANK binding kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| frontotemporal dementia and/or amyotrophic lateral sclerosis 4 | Alliance | Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 | 616439 |
| Autoinflammation with arthritis and vasculitis | 620880 | ||
| {Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8} | 617900 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR041087 | TANK binding kinase 1, ubiquitin-like domain |
| Domain | IPR041309 | TANK-binding kinase 1, coiled-coil domain 1 |
| Family | IPR051180 | Inhibitor of nuclear factor kappa-B kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Inhibitor of nuclear factor kappa-B kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | TANK-binding kinase 1, coiled-coil domain 1 | TANK binding kinase 1, ubiquitin-like domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q0GKD6
|
727 |
Interactions and Pathways
No data available
Plasmids
No data available