Gene
nkd3
- ID
- ZDB-GENE-060503-63
- Name
- NKD inhibitor of WNT signaling pathway 3
- Symbol
- nkd3 Nomenclature History
- Previous Names
-
- si:dkey-231l1.4
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within Kupffer's vesicle development. Predicted to be located in cytoplasm and plasma membrane. Is expressed in blastoderm; blastodisc; somite; and tail bud.
- Genome Resources
-
- Alliance (1)
- Gene:566577 (1)
- VEGA:OTTDARG00000015673 (1)
- VEGA:OTTDARG00000037795 (1)
- VEGA:OTTDARG00000037796 (1)
- VEGA:OTTDARG00000037797 (1)
- VEGA:OTTDARG00000037798 (1)
- Ensembl(GRCz11):ENSDARG00000013174 (2)
- Ensembl(GRCz11):ENSDARG00000069984 (1)
- Ensembl(GRCz11):ENSDARG00000086218 (1)
- Ensembl(GRCz11):ENSDARG00000096278 (1)
- Ensembl(GRCz11):ENSDARG00000096299 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Schneider et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Schneider et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Length |
|---|---|
|
UniProtKB:A7E2G4
|
448 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-231L1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171243 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174181 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100405 (1) | 1824 nt | ||
| Genomic | GenBank:CR786578 | 175254 nt | ||
| Polypeptide | UniProtKB:A7E2G4 (1) | 448 aa |
No data available
- Zhou, S., Wei, Z., Chu, T., Yu, H., Li, S., Zhang, W., Gui, W. (2018) Transcriptomic analysis of zebrafish (Danio rerio) embryos to assess integrated biotoxicity of Xitiaoxi River waters. Environmental pollution (Barking, Essex : 1987). 242:42-53
- Marsden, A.N., Derry, S.W., Schneider, I., Scott, C.A., Westfall, T.A., Brastrom, L.K., Shea, M., Dawson, D.V., Slusarski, D.C. (2017) The Nkd EF-Hand Domain Modulates Divergent Wnt Signaling Outputs in Zebrafish. Developmental Biology. 434(1):63-73
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Schneider, I., Schneider, P.N., Derry, S.W., Lin, S., Barton, L.J., Westfall, T., and Slusarski, D.C. (2010) Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Developmental Biology. 348(1):22-33
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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