Gene
kcnn1b
- ID
- ZDB-GENE-060503-397
- Name
- potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1b
- Symbol
- kcnn1b Nomenclature History
- Previous Names
-
- kcnn1
- sk1 (1)
- si:ch211-200a16.1
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable calmodulin binding activity and small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in membrane. Predicted to be active in neuron projection; neuronal cell body; and plasma membrane. Is expressed in head; heart; and nervous system. Orthologous to human KCNN1 (potassium calcium-activated channel subfamily N member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016258Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calmodulin-binding domain | Potassium channel, calcium-activated, SK | Potassium channel domain | SK, calmodulin-binding domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IC13
|
547 | ||||
|
UniProtKB:A0A8M2BE84
|
811 | ||||
|
UniProtKB:A0A8M9Q9S4
|
609 | ||||
|
UniProtKB:Q1LY45
|
235 | ||||
|
UniProtKB:A0A8M9Q3J1
|
814 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnn1b-201
(1)
|
Ensembl | 1,180 nt | ||
| mRNA |
kcnn1b-202
(1)
|
Ensembl | 1,800 nt | ||
| mRNA |
kcnn1b-203
(1)
|
Ensembl | 1,410 nt | ||
| mRNA |
kcnn1b-204
(1)
|
Ensembl | 1,644 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-kcnn1b | polyclonal | Goat |
|
Santa Cruz Biotechnology, Inc.
|
2 |
1 - 1 of 1
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-200A16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171321 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328106 (1) | 1949 nt | ||
| Genomic | GenBank:BX119975 (1) | 154904 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q3J1 (1) | 814 aa |
- Silic, M.R., Black, M.M., Zhang, G. (2021) Phylogenetic and developmental analyses indicate complex functions of Calcium-Activated Potassium Channels in zebrafish embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(10):1477-1493
- Carpaneto Freixas, A.E., Moglie, M.J., Castagnola, T., Salatino, L., Domene, S., Marcovich, I., Gallino, S., Wedemeyer, C., Goutman, J.D., Plazas, P.V., Elgoyhen, A.B. (2020) Unravelling the molecular players at the cholinergic efferent synapse of the zebrafish lateral line. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(1):47-60
- Ding, X., Sun, W., Dai, L., Liu, C., Sun, Q., Wang, J., Zhang, P., Li, K., Yu, L. (2020) Parental exposure to environmental concentrations of tris(1,3-dichloro-2-propyl)phosphate induces abnormal DNA methylation and behavioral changes in F1 zebrafish larvae. Environmental pollution (Barking, Essex : 1987). 267:115305
- Skarsfeldt, M.A., Bomholtz, S.H., Lundegaard, P.R., Lopez-Izquierdo, A., Tristani-Firouzi, M., Bentzen, B.H. (2018) Atrium-specific ion channels in the zebrafish-A role of IKACh in atrial repolarization.. Acta physiologica (Oxford, England). 223(3):e13049
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Cabo, R., Zichichi, R., Viña, E., Guerrera, M.C., Vázquez, G., García-Suárez, O., Vega, J.A., and Germanà, A. (2013) Calcium-activated potassium channel SK1 is widely expressed in the peripheral nervous system and sensory organs of adult zebrafish. Neuroscience letters. 555:62-67
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Liongue, C., O'Sullivan. L.A., Trengove, M.C., and Ward, A.C. (2012) Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS One. 7(3):e32777
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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