Gene

lnx2a

ID

ZDB-GENE-060228-2

Name

ligand of numb-protein X 2a

Symbol

lnx2a Nomenclature History

Previous Names

lnx2

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Exhibits ubiquitin protein ligase activity. Involved in exocrine pancreas development. Is expressed in central nervous system; endoderm; and pancreatic system. Orthologous to human LNX2 (ligand of numb-protein X 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Won et al., 2015

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from Won et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lnx2a Human Ortholog

No data available

Associated With lnx2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR001478	PDZ domain
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR018957	Zinc finger, C3HC4 RING-type
Family	IPR051342	PDZ domain-containing scaffold protein
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	PDZ domain	PDZ domain-containing scaffold protein	PDZ superfamily	Zinc finger, C3HC4 RING-type	Zinc finger, RING/FYVE/PHD-type	Zinc finger, RING-type	Zinc finger, RING-type, conserved site
UniProtKB:A0A8M9PU28 InterPro	567
UniProtKB:A0A8M9PXH3 InterPro	587
UniProtKB:F1R5N4 InterPro	737
UniProtKB:B6DRF5 InterPro	737
UniProtKB:A0A8M9PLS6 InterPro	628