Gene
hmgcrb
- ID
- ZDB-GENE-051108-1
- Name
- 3-hydroxy-3-methylglutaryl-CoA reductase b
- Symbol
- hmgcrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have hydroxymethylglutaryl-CoA reductase (NADPH) activity and hydroxymethylglutaryl-CoA reductase activity. Involved in animal organ development and blood vessel maturation. Predicted to localize to endoplasmic reticulum membrane and peroxisomal membrane. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Is expressed in liver; notochord; and polster. Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6912716 (1 image)
- IMAGE:6904727 (2 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR023076 | Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site |
Domain | IPR000731 | Sterol-sensing domain |
Family | IPR002202 | Hydroxymethylglutaryl-CoA reductase, class I/II |
Family | IPR004554 | Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type |
Family | IPR004816 | Hydroxymethylglutaryl-CoA reductase, metazoan |
Homologous_superfamily | IPR009023 | Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily |
Homologous_superfamily | IPR009029 | Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily |
Homologous_superfamily | IPR023074 | Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily |
Homologous_superfamily | IPR023282 | Hydroxymethylglutaryl-CoA reductase, N-terminal |
Domain Details Per Protein
Protein | Length | Hydroxymethylglutaryl-CoA reductase, class I/II | Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily | Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site | Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily | Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily | Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type | Hydroxymethylglutaryl-CoA reductase, metazoan | Hydroxymethylglutaryl-CoA reductase, N-terminal | Sterol-sensing domain |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q58ER2
|
845 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
hmgcrb-201
(1)
|
Havana | 3424 nt |
Interactions and Pathways
No data available
Plasmids
No data available