Gene
itga2b
- ID
- ZDB-GENE-051031-1
- Name
- integrin, alpha 2b
- Symbol
- itga2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Involved in angiogenesis; blood coagulation; and endothelial cell proliferation. Localizes to integrin complex. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Is expressed in blood; thrombocyte; and ventral wall of dorsal aorta. Orthologous to human ITGA2B (integrin subunit alpha 2b).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Glanzmann's thrombasthenia | Alliance | Glanzmann thrombasthenia 1 | 273800 |
| platelet-type bleeding disorder 16 | Alliance | Bleeding disorder, platelet-type, 16, autosomal dominant | 187800 |
| Thrombocytopenia, neonatal alloimmune, BAK antigen related |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018184 | Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
| Domain | IPR013649 | Integrin alpha, first immunoglubulin-like domain |
| Domain | IPR048285 | Integrin alpha, second immunoglobulin-like domain |
| Domain | IPR048286 | Integrin alpha, third immunoglobulin-like domain |
| Family | IPR000413 | Integrin alpha chain |
| Homologous_superfamily | IPR028994 | Integrin alpha, N-terminal |
| Homologous_superfamily | IPR032695 | Integrin domain superfamily |
| Repeat | IPR013517 | FG-GAP repeat |
| Repeat | IPR013519 | Integrin alpha beta-propellor |
Domain Details Per Protein
| Protein | Length | FG-GAP repeat | Integrin alpha beta-propellor | Integrin alpha chain | Integrin alpha chain, C-terminal cytoplasmic region, conserved site | Integrin alpha, first immunoglubulin-like domain | Integrin alpha, N-terminal | Integrin alpha, second immunoglobulin-like domain | Integrin alpha, third immunoglobulin-like domain | Integrin domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6EIY7
|
1037 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
itga2b-201
(1)
|
Ensembl | 3,755 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab3-itga2b | monoclonal | Mouse |
|
1 | |||
| Ab1-itga2b | polyclonal | Rabbit |
|
1 |
Plasmids
No data available