Gene
mpi
- ID
- ZDB-GENE-050904-6
- Name
- mannose phosphate isomerase
- Symbol
- mpi Nomenclature History
- Previous Names
-
- im:7140016
- zgc:110773
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Exhibits mannose-6-phosphate isomerase activity. Involved in chondrocyte morphogenesis; chordate embryonic development; and liver development. Predicted to localize to cytosol. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Is expressed in several structures, including female organism; margin; nervous system; neural tube; and polster. Orthologous to human MPI (mannose phosphate isomerase).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7140016 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
congenital disorder of glycosylation Ib | Alliance | Congenital disorder of glycosylation, type Ib | 602579 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
congenital disorder of glycosylation type I | AB + MO1-mpi | standard conditions | Chu et al., 2013 |
congenital disorder of glycosylation type I | WT + MO1-mpi | standard conditions | DeRossi et al., 2019 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018050 | Phosphomannose isomerase, type I, conserved site |
Domain | IPR046456 | Phosphomannose isomerase type I, C-terminal domain |
Domain | IPR046457 | Phosphomannose isomerase type I, catalytic domain |
Domain | IPR046458 | Phosphomannose isomerase type I, helical insertion domain |
Family | IPR001250 | Mannose-6-phosphate isomerase, type I |
Family | IPR016305 | Mannose-6-phosphate isomerase |
Homologous_superfamily | IPR011051 | RmlC-like cupin domain superfamily |
Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
Domain Details Per Protein
Protein | Length | Mannose-6-phosphate isomerase | Mannose-6-phosphate isomerase, type I | Phosphomannose isomerase type I, catalytic domain | Phosphomannose isomerase, type I, conserved site | Phosphomannose isomerase type I, C-terminal domain | Phosphomannose isomerase type I, helical insertion domain | RmlC-like cupin domain superfamily | RmlC-like jelly roll fold |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q3ZB95
|
422 |
Interactions and Pathways
No data available
Plasmids
No data available