Gene
myh11a
- ID
- ZDB-GENE-050531-1
- Name
- myosin, heavy chain 11a, smooth muscle
- Symbol
- myh11a Nomenclature History
- Previous Names
-
- myh11
- meltdown
- mlt
- smmhc (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in several processes, including digestive tract morphogenesis; heart contraction; and regulation of polarized epithelial cell differentiation. Predicted to localize to myosin complex. Is expressed in gut and muscle. Used to study megacystis-microcolon-intestinal hypoperistalsis syndrome. Human ortholog(s) of this gene implicated in patent ductus arteriosus and thoracic aortic aneurysm. Orthologous to human MYH11 (myosin heavy chain 11).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 17 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
thoracic aortic aneurysm | Alliance | Aortic aneurysm, familial thoracic 4 | 132900 |
Megacystis-microcolon-intestinal hypoperistalsis syndrome 2 | 619351 | ||
Visceral myopathy 2 | 619350 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001609 | Myosin head, motor domain |
Domain | IPR002928 | Myosin tail |
Domain | IPR004009 | Myosin, N-terminal, SH3-like |
Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
Protein | Length | Kinesin motor domain superfamily | Myosin head, motor domain | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|
UniProtKB:Q4U0S2
|
1974 | ||||||
UniProtKB:A0A8M9QAD3
|
1943 | ||||||
UniProtKB:A0A8M9QFE6
|
1983 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
myh11a-201
(1)
|
Ensembl | 7,086 nt | ||
mRNA |
myh11a-202
(1)
|
Ensembl | 531 nt |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-myh11 | polyclonal | IgG | Rabbit |
|
Biomedical Technologies, Inc.
|
10 |
Plasmids
No data available