Gene
abcb11b
- ID
- ZDB-GENE-050517-14
- Name
- ATP-binding cassette, sub-family B (MDR/TAP), member 11b
- Symbol
- abcb11b Nomenclature History
- Previous Names
-
- bsep (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have ATPase-coupled transmembrane transporter activity and canalicular bile acid transmembrane transporter activity. Involved in bile acid secretion. Predicted to localize to integral component of membrane. Used to study progressive familial intrahepatic cholestasis 2. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Is expressed in liver. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Ellis et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
benign recurrent intrahepatic cholestasis 2 | Alliance | Cholestasis, benign recurrent intrahepatic, 2 | 605479 |
progressive familial intrahepatic cholestasis 2 | Alliance | Cholestasis, progressive familial intrahepatic 2 | 601847 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
progressive familial intrahepatic cholestasis 2 | abcb11bci200/ci200 | standard conditions | Ellis et al., 2017 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017871 | ABC transporter-like, conserved site |
Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
Domain | IPR003593 | AAA+ ATPase domain |
Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
Family | IPR039421 | Type 1 protein exporter |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Homologous_superfamily | IPR036640 | ABC transporter type 1, transmembrane domain superfamily |
Domain Details Per Protein
Protein | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Type 1 protein exporter |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M1RNN7
|
1348 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
abcb11b-201
(1)
|
Ensembl | 7530 nt | |
mRNA |
abcb11b-202
(1)
|
Havana | 4463 nt | |
mRNA |
abcb11b-203
(1)
|
Ensembl | 7443 nt |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-abcb11 | polyclonal | Rabbit |
|
Kamiya Biomedical Company
|
18 |
Plasmids
No data available