Gene
vcla
- ID
- ZDB-GENE-050506-61
- Name
- vinculin a
- Symbol
- vcla Nomenclature History
- Previous Names
-
- vcl
- hm:zehn2160
- im:6902790
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have actin filament binding activity and structural molecule activity. Involved in heart contraction; membrane repolarization during cardiac muscle cell action potential; and sarcomere organization. Localizes to adherens junction and focal adhesion. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Is expressed in several structures, including heart; lens; pectoral fin; solid lens vesicle; and somite. Orthologous to human VCL (vinculin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6902790 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1W | Alliance | Cardiomyopathy, dilated, 1W | 611407 |
| hypertrophic cardiomyopathy 15 | Alliance | Cardiomyopathy, hypertrophic, 15 | 613255 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Alpha-catenin/vinculin-like superfamily | Vinculin | Vinculin/alpha-catenin | Vinculin, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:F6NHA0
|
1066 | ||||
|
UniProtKB:A0A8M2B3M1
|
1130 | ||||
|
UniProtKB:A0A8M9QJN2
|
1067 | ||||
|
UniProtKB:B3DI32
|
1131 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab6-vcl | monoclonal | IgG1 | Mouse |
|
Sigma-Aldrich
|
14 |
Plasmids