Gene

ca8

ID
ZDB-GENE-050417-26
Name
carbonic anhydrase VIII
Symbol
ca8 Nomenclature History
Previous Names
  • CARP VIII (1)
  • zgc:110118 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have carbonate dehydratase activity and zinc ion binding activity. Involved in cerebellum development; chordate embryonic development; and swimming behavior. Used to study cerebellar ataxia, mental retardation and dysequlibrium syndrome. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome. Is expressed in several structures, including brain; digestive system; hatching gland; hindbrain neural plate; and pleuroperitoneal region. Orthologous to human CA8 (carbonic anhydrase 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ca8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 3 Alliance Spinocerebellar ataxia, autosomal recessive 34 613227
Associated With ca8 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018338 Carbonic anhydrase, alpha-class, conserved site
Domain IPR001148 Alpha carbonic anhydrase domain
Family IPR023561 Carbonic anhydrase, alpha-class
Family IPR041877 Carbonic anhydrase-related protein VIII
Homologous_superfamily IPR036398 Alpha carbonic anhydrase domain superfamily
Domain Details Per Protein
Protein Length Alpha carbonic anhydrase domain Alpha carbonic anhydrase domain superfamily Carbonic anhydrase, alpha-class Carbonic anhydrase, alpha-class, conserved site Carbonic anhydrase-related protein VIII
UniProtKB:Q568S6 281
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ca8-201 (1) Ensembl 2,174 nt
mRNA ca8-202 (1) Ensembl 902 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-ca8 monoclonal Mouse
3
Ab1-ca8 polyclonal IgG Rabbit
  • IHC
  • WB
Santa Cruz Biotechnology, Inc.
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations