Gene
trim2a
- ID
- ZDB-GENE-050327-99
- Name
- tripartite motif containing 2a
- Symbol
- trim2a Nomenclature History
- Previous Names
-
- trim2 (1)
- zgc:113099
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have ubiquitin protein ligase activity. Involved in myeloid cell differentiation and primitive hemopoiesis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Is expressed in blood cell and vascular endothelium. Orthologous to human TRIM2 (tripartite motif containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Cannon et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Cannon et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 2R | Alliance | Charcot-Marie-Tooth disease, type 2R | 615490 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR000315 | B-box-type zinc finger |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR003649 | B-box, C-terminal |
| Domain | IPR027370 | Zinc finger, RING-type, eukaryotic |
| Family | IPR050952 | Tripartite Motif and NHL Repeat Containing E3 Ligases |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Repeat | IPR001258 | NHL repeat |
| Repeat | IPR001298 | Filamin/ABP280 repeat |
| Repeat | IPR017868 | Filamin/ABP280 repeat-like |
Domain Details Per Protein
| Protein | Length | B-box, C-terminal | B-box-type zinc finger | Filamin/ABP280 repeat | Filamin/ABP280 repeat-like | Immunoglobulin E-set | Immunoglobulin-like fold | NHL repeat | Six-bladed beta-propeller, TolB-like | Tripartite Motif and NHL Repeat Containing E3 Ligases | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site | Zinc finger, RING-type, eukaryotic |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BIL2
|
520 | |||||||||||||
|
UniProtKB:Q58ER5
|
744 | |||||||||||||
|
UniProtKB:F1QFW2
|
744 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
trim2a-201
(1)
|
Ensembl | 3,089 nt |
Interactions and Pathways
No data available
Plasmids
No data available