Gene

eya4

ID

ZDB-GENE-050327-93

Name

EYA transcriptional coactivator and phosphatase 4

Symbol

eya4 Nomenclature History

Previous Names

im:7221408
zgc:113079

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have protein tyrosine phosphatase activity. Involved in embryonic organ development; posterior lateral line neuromast hair cell differentiation; and startle response. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 10; congestive heart failure; dilated cardiomyopathy; dilated cardiomyopathy 1J; and sensorineural hearing loss. Is expressed in several structures, including otic epithelium; otic vesicle; pericardial region; pharyngeal arch; and sensory system. Orthologous to human EYA4 (EYA transcriptional coactivator and phosphatase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Wang et al., 2008
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eya4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 10	Alliance	Deafness, autosomal dominant 10	601316
dilated cardiomyopathy 1J	Alliance	?Cardiomyopathy, dilated, 1J	605362

Associated With eya4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006545	EYA domain
Domain	IPR042577	EYA domain, metazoan
Family	IPR028472	Eyes absent family
Homologous_superfamily	IPR038102	EYA domain superfamily

Domain Details Per Protein

Protein	Length	EYA domain	EYA domain, metazoan	EYA domain superfamily	Eyes absent family
UniProtKB:A0A8M9PT27 InterPro	635
UniProtKB:A0A8M9PT22 InterPro	641
UniProtKB:A0A8M2B979 InterPro	638
UniProtKB:A0A8M9PKQ9 InterPro	640
UniProtKB:A0A8M3AYM8 InterPro	610
UniProtKB:A0A8M9PWH1 InterPro	639
UniProtKB:E9QGZ3 InterPro	636
UniProtKB:E9QIR1 InterPro	613
UniProtKB:A0A0R4IA41 InterPro	638
UniProtKB:A0A8M9PF15 InterPro	640
UniProtKB:A0A8M9P540 InterPro	641

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	eya4-201 (1) Ensembl	Ensembl	1,974 nt	Select Tool
mRNA	eya4-202 (1) Ensembl	Ensembl	1,911 nt	Select Tool
mRNA	eya4-203 (1) Ensembl	Ensembl	1,911 nt	Select Tool
mRNA	eya4-204 (1) Ensembl	Ensembl	2,414 nt	Select Tool
mRNA	eya4-205 (1) Ensembl	Ensembl	2,890 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations