Gene
kif7
- ID
- ZDB-GENE-050307-1
- Name
- kinesin family member 7
- Symbol
- kif7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have ATPase activity; microtubule binding activity; and microtubule motor activity. Involved in determination of left/right symmetry; negative regulation of smoothened signaling pathway; and photoreceptor cell outer segment organization. Localizes to Hedgehog signaling complex; cilium; and cytoplasm. Human ortholog(s) of this gene implicated in acrocallosal syndrome; cleft lip; and hydrolethalus syndrome 2. Is expressed in myotome; neural tube; otic vesicle; and somite. Orthologous to human KIF7 (kinesin family member 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acrocallosal syndrome | Alliance | Acrocallosal syndrome | 200990 |
| acrocallosal syndrome | Alliance | Joubert syndrome 12 | 200990 |
| hydrolethalus syndrome 2 | Alliance | ?Hydrolethalus syndrome 2 | 614120 |
| ?Al-Gazali-Bakalinova syndrome | 607131 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| idiopathic scoliosis | kif7co63/co63 (AB) | standard conditions | (2) |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Family | IPR027640 | Kinesin-like protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
|
UniProtKB:F1QH25
|
1363 | |||||
|
UniProtKB:Q58G59
|
1363 |
Interactions and Pathways
Plasmids
No data available