Gene

cpamd8

ID

ZDB-GENE-050208-428

Name

C3 and PZP like alpha-2-macroglobulin domain containing 8

Symbol

cpamd8 Nomenclature History

Previous Names

si:ch211-87h14.4
si:dkey-94n12.1

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have endopeptidase inhibitor activity. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in anterior segment dysgenesis 8. Orthologous to human CPAMD8 (C3 and PZP like alpha-2-macroglobulin domain containing 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Bonet-Fernández et al., 2020

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Bonet-Fernández et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cpamd8 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
anterior segment dysgenesis 8	Alliance	Anterior segment dysgenesis 8	617319

Associated With cpamd8 Via Experimental Models

Human Disease	Fish	Conditions	Citations
anterior segment dysgenesis	WT + CRISPR4-cpamd8 + CRISPR5-cpamd8	standard conditions	Bonet-Fernández et al., 2020
anterior segment dysgenesis	WT + CRISPR2-cpamd8 + CRISPR3-cpamd8	standard conditions	Bonet-Fernández et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019742	Alpha-2-macroglobulin, conserved site
Conserved_site	IPR047565	Alpha-macroglobulin-like, thiol-ester bond-forming region
Domain	IPR001599	Alpha-2-macroglobulin
Domain	IPR002350	Kazal domain
Domain	IPR002890	Macroglobulin domain
Domain	IPR009048	Alpha-macroglobulin, receptor-binding
Domain	IPR011625	Alpha-2-macroglobulin, bait region domain
Domain	IPR011626	Alpha-macroglobulin-like, TED domain
Domain	IPR022041	Farnesoic acid O-methyl transferase
Domain	IPR040839	Macroglobulin domain MG4
Domain	IPR041555	Macroglobulin domain MG3
Domain	IPR041813	Alpha-2-macroglobulin, TED domain
Family	IPR050473	Alpha-2-macroglobulin/Complement system
Homologous_superfamily	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014756	Immunoglobulin E-set
Homologous_superfamily	IPR036058	Kazal domain superfamily
Homologous_superfamily	IPR036595	Alpha-macroglobulin, receptor-binding domain superfamily

Domain Details Per Protein

Protein	Length	Alpha-2-macroglobulin	Alpha-2-macroglobulin, bait region domain	Alpha-2-macroglobulin/Complement system	Alpha-2-macroglobulin, conserved site	Alpha-2-macroglobulin, TED domain	Alpha-macroglobulin-like, TED domain	Alpha-macroglobulin-like, thiol-ester bond-forming region	Alpha-macroglobulin, receptor-binding	Alpha-macroglobulin, receptor-binding domain superfamily	Farnesoic acid O-methyl transferase	Immunoglobulin E-set	Immunoglobulin-like fold	Kazal domain	Kazal domain superfamily	Macroglobulin domain	Macroglobulin domain MG3	Macroglobulin domain MG4	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
UniProtKB:A0A8M1RP87 InterPro	1860

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cpamd8-201 (1) Ensembl	Ensembl	1,563 nt	Select Tool ZFIN BLAST
mRNA	cpamd8-202 (1) Ensembl	Ensembl	6,613 nt	Select Tool
ncRNA	cpamd8-002 (1) Ensembl	Ensembl	809 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-cpamd8	polyclonal	cpamd8		Rabbit	IHC	Sigma-Aldrich	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations