Gene

prkcaa

ID

ZDB-GENE-050208-100

Name

protein kinase C, alpha, a

Symbol

prkcaa Nomenclature History

Previous Names

prkca
im:7139045 (1)
si:dkey-8l19.1 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Involved in blood coagulation. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; large cell carcinoma; malignant glioma (multiple); and reproductive organ cancer (multiple). Is expressed in EVL; hatching gland; nervous system; neural tube; and trigeminal placode. Orthologous to human PRKCA (protein kinase C alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 8 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7139045 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Williams et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkcaa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Pituitary tumor, invasive

Associated With prkcaa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000008	C2 domain
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain	IPR017892	Protein kinase, C-terminal
Domain	IPR020454	Diacylglycerol/phorbol-ester binding
Domain	IPR034663	Classical Protein Kinase C alpha, catalytic domain
Family	IPR014375	Protein kinase C, alpha/beta/gamma types
Family	IPR050236	Serine/threonine-protein kinases, AGC
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR046349	C1-like domain superfamily

Domain Details Per Protein

Protein	Length	AGC-kinase, C-terminal	C1-like domain superfamily	C2 domain	C2 domain superfamily	Classical Protein Kinase C alpha, catalytic domain	Diacylglycerol/phorbol-ester binding	Protein kinase, ATP binding site	Protein kinase C, alpha/beta/gamma types	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Protein kinase, C-terminal	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine/threonine-protein kinases, AGC
UniProtKB:A0A2R8QIY5 InterPro	670
UniProtKB:A0A8M9PM31 InterPro	679

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	prkca-001 (1) Ensembl	Ensembl		2,172 nt	Select Tool
mRNA	prkcaa-202 (1) Ensembl	Ensembl		6,143 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-prkca	polyclonal	prkcaa	IgG	Rabbit	IHC	Santa Cruz Biotechnology, Inc.	6
Ab1-prkca	polyclonal	prkcaa	IgG	Rabbit	IHC WB	Santa Cruz Biotechnology, Inc.	25

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations