Gene

slc26a3.1

ID

ZDB-GENE-041210-180

Name

solute carrier family 26 member 3

Symbol

slc26a3.1 Nomenclature History

Previous Names

slc26a3
si:dkey-31f5.2

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Exhibits sodium:bicarbonate symporter activity. Involved in anion homeostasis; chloride transport; and response to salt stress. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in congenital secretory chloride diarrhea 1 and diarrhea. Is expressed in several structures, including gill; heart; lateral line system; liver; and pleuroperitoneal region. Orthologous to human SLC26A3 (solute carrier family 26 member 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Bayaa et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc26a3.1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital secretory chloride diarrhea 1	Alliance	Diarrhea 1, secretory chloride, congenital	214700

Associated With slc26a3.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018045	Sulphate anion transporter, conserved site
Domain	IPR002645	STAS domain
Domain	IPR011547	SLC26A/SulP transporter domain
Family	IPR001902	SLC26A/SulP transporter
Homologous_superfamily	IPR036513	STAS domain superfamily