Gene

nexn

ID
ZDB-GENE-041114-92
Name
nexilin (F actin binding protein)
Symbol
nexn Nomenclature History
Previous Names
  • zgc:103442 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have cell-cell adhesion mediator activity. Involved in cardiac muscle fiber development. Localizes to Z disc. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1CC and hypertrophic cardiomyopathy 20. Is expressed in adaxial cell; cardiovascular system; musculature system; and somite. Orthologous to human NEXN (nexilin F-actin binding protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Hassel et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nexn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dilated cardiomyopathy 1CC Alliance Cardiomyopathy, dilated, 1CC 613122
hypertrophic cardiomyopathy 20 Alliance Cardiomyopathy, hypertrophic, 20 613876
Associated With nexn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003599 Immunoglobulin domain subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin domain subtype Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold
UniProtKB:A2BEV6 861
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
aberrant processed transcript al844185.1-201 (1) Ensembl 907 nt
mRNA nexn-201 (1) Ensembl 2,442 nt
mRNA nexn-202 (1) Ensembl 3,338 nt
mRNA nexn-204 (1) Ensembl 785 nt
mRNA nexn-206 (1) Ensembl 987 nt
mRNA nexn-208 (1) Ensembl 4,774 nt
mRNA nexn-209 (1) Ensembl 4,726 nt
ncRNA nexn-002 (1) Ensembl 653 nt
ncRNA nexn-005 (1) Ensembl 819 nt
ncRNA nexn-006 (1) Ensembl 361 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations