Gene

rfx6

ID

ZDB-GENE-041014-299

Name

regulatory factor X, 6

Symbol

rfx6 Nomenclature History

Previous Names

si:dkeyp-93d12.2

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in endocrine pancreas development. Predicted to localize to nucleus. Is expressed in intestine; pancreas; pancreas primordium; and pancreatic bud. Orthologous to human RFX6 (regulatory factor X6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Soyer et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rfx6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Mitchell-Riley syndrome	615710

Associated With rfx6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003150	DNA-binding RFX-type winged-helix domain
Family	IPR039779	RFX-like DNA-binding protein
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily