Gene
hgfa
- ID
- ZDB-GENE-041014-2
- Name
- hepatocyte growth factor a
- Symbol
- hgfa Nomenclature History
- Previous Names
-
- hgf1
- si:dkey-146j3.2
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor binding activity. Acts upstream of or within cerebellar granule cell differentiation; cranial nerve formation; and neuron migration. Predicted to be active in extracellular space. Is expressed in several structures, including DEL; adaxial cell; axis; endodermal cell; and forebrain neural rod. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Isabella et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh528 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| fh529 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa10071 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa10507 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20261 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38437 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 39 | Alliance | Deafness, autosomal recessive 39 | 608265 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Hepatocyte growth factor | Hepatocyte growth factor/Macrophage stimulatory protein | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | PAN/Apple domain | Peptidase S1A, chymotrypsin family | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine proteases and regulators with kringle domains | Serine proteases, trypsin domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1REK1
|
712 | ||||||||||||
|
UniProtKB:Q5RGG3
|
699 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-146J3 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7144651 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:162497 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013274 (1) | 2249 nt | ||
| Genomic | GenBank:BX323820 (1) | 172228 nt | ||
| Polypeptide | UniProtKB:F1REK1 (1) | 712 aa |
- Fang, Y., Wan, J.P., Wang, Z., Song, S.Y., Zhang, C.X., Yang, L., Zhang, Q.Y., Yan, C.Y., Wu, F.Y., Lu, S.Y., Sun, F., Han, B., Zhao, S.X., Dong, M., Song, H.D. (2024) Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion. Nature communications. 15:31653165
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
- Ali, M.F., Latimer, A.J., Wang, Y., Hogenmiller, L., Fontenas, L., Isabella, A.J., Moens, C.B., Yu, G., Kucenas, S. (2021) Met is required for oligodendrocyte progenitor cell migration in Danio rerio. G3 (Bethesda). 11(10):
- Chiang, K.Y., Li, Y.W., Li, Y.H., Huang, S.J., Wu, C.L., Gong, H.Y., Wu, J.L. (2021) Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish. International Journal of Molecular Sciences. 22(20):
- Isabella, A.J., Barsh, G.R., Stonick, J.A., Dubrulle, J., Moens, C.B. (2020) Retinoic Acid Organizes the Zebrafish Vagus Motor Topographic Map via Spatiotemporal Coordination of Hgf/Met Signaling. Developmental Cell. 53(3):344-357.e5
- Talbot, J.C., Teets, E.M., Ratnayake, D., Duy, P.Q., Currie, P.D., Amacher, S.L. (2019) Muscle precursor cell movements in zebrafish are dynamic and require six-family genes. Development (Cambridge, England). 146(10):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Pei, W., LaFave, M.C., Idol, J., Xu, L., Gallardo, V., Carrington, B., Bishop, K., Jones, M., Li, M., Harper, U., Huang, S.C., Prakash, A., Chen, W., Sood, R., Ledin, J., Burgess, S.M. (2015) High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome research. 25(7):1030-42
- Anderson, R.M., Delous, M., Bosch, J.A., Ye, L., Robertson, M.A., Hesselson, D., and Stainier, D.Y. (2013) Hepatocyte Growth Factor Signaling in Intrapancreatic Ductal Cells Drives Pancreatic Morphogenesis. PLoS Genetics. 9(7):e1003650
- Li, Y.H., Chen, M.H., Gong, H.Y., Hu, S.Y., Li, Y.W., Lin, G.H., Lin, C.C., Liu, W., and Wu, J.L. (2010) Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish. The Journal of biological chemistry. 285(52):41001-41009
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