Gene

gsx1

ID
ZDB-GENE-041008-135
Name
GS homeobox 1
Symbol
gsx1 Nomenclature History
Previous Names
  • gsh1 (1)
  • im:7138106
  • zgc:110817 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in central nervous system and presumptive rhombomere 3. Orthologous to human GSX1 (GS homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Coltogirone et al., 2022
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa33771Allele with one point mutationUnknownSplice Site, Premature StopENU
y689Allele with one deletionExon 1Frameshift, Premature StopTALEN
y690Allele with one deletionExon 1Frameshift, Premature StopTALEN
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Sequence Targeting Reagents
No data available
Human Disease
Associated With gsx1 Human Ortholog
No data available
Associated With gsx1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR020479 Homeodomain, metazoa
Family IPR042191 GS homeobox 1/2
Homologous_superfamily IPR009057 Homedomain-like superfamily
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Domain Details Per Protein
Protein Length GS homeobox 1/2 Homedomain-like superfamily Homeobox, conserved site Homeodomain Homeodomain, metazoa
UniProtKB:Q5QHS3 243
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 5
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gsx1-201 (1) Ensembl 1,379 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
TgBAC(gsx1:Cre)
  • gsx1
  • Danio rerio
1 (3)
TgBAC(gsx1:GFP)
  • gsx1
  • Danio rerio
1 (3)
TgBAC(gsx1:LOXP-RFP-LOXP-GFP)
  • gsx1
  • Danio rerio
1 (2)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-91M11ZFIN Curated Data
Contained inBACCH211-271B14ZFIN Curated Data
EncodesESTIMAGE:7138106Thisse et al., 2004
EncodescDNAMGC:110817ZFIN Curated Data
EncodescDNAMGC:192225ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanGSX113
Amino acid sequence comparison (2)
Phylogenetic tree (1)
Conserved genome location (synteny) (2)
MouseGsx15
Conserved genome location (synteny) (1)
Phylogenetic tree (1)
Amino acid sequence comparison (2)
Fruit flyind3L
Amino acid sequence comparison (1)
Citations
1 - 10 of 16
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