Gene
gsx1
- ID
- ZDB-GENE-041008-135
- Name
- GS homeobox 1
- Symbol
- gsx1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in central nervous system and presumptive rhombomere 3. Orthologous to human GSX1 (GS homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 20 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138106 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Coltogirone et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | GS homeobox 1/2 | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
---|---|---|---|---|---|---|
UniProtKB:Q5QHS3
|
243 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
TgBAC(gsx1:Cre) |
|
| 1 | (3) | |
TgBAC(gsx1:GFP) |
|
| 1 | (3) | |
TgBAC(gsx1:LOXP-RFP-LOXP-GFP) |
|
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-91M11 | ZFIN Curated Data | |
Contained in | BAC | CH211-271B14 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7138106 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:110817 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192225 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001012251 (1) | 1401 nt | ||
Genomic | GenBank:CU861887 (1) | 173511 nt | ||
Polypeptide | UniProtKB:Q5QHS3 (1) | 243 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | GSX1 | 13 | Amino acid sequence comparison (2) Phylogenetic tree (1) Conserved genome location (synteny) (2) | |
Mouse | Gsx1 | 5 | Conserved genome location (synteny) (1) Phylogenetic tree (1) Amino acid sequence comparison (2) | |
Fruit fly | ind | 3L | Amino acid sequence comparison (1) |
- Schmidt, A.R., Placer, H.J., Muhammad, I.M., Shephard, R., Patrick, R.L., Saurborn, T., Horstick, E.J., Bergeron, S.A. (2024) Transcriptional control of visual neural circuit development by GS homeobox 1. PLoS Genetics. 20:e1011139e1011139
- Coltogirone, R.A., Sherfinski, E.I., Dobler, Z.A., Peterson, S.N., Andlinger, A.R., Fadel, L.C., Patrick, R.L., Bergeron, S.A. (2022) Gsx2, but not Gsx1, is necessary for early forebrain patterning and long-term survival in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(3):377-399
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
- Rojo-Bartolomé, I., Santana de Souza, J.E., Diaz de Cerio, O., Cancio, I. (2020) Duplication and subfunctionalisation of the general transcription factor IIIA (gtf3a) gene in teleost genomes, with ovarian specific transcription of gtf3ab. PLoS One. 15:e0227690
- Loponte, S., Segré, C.V., Senese, S., Miccolo, C., Santaguida, S., Deflorian, G., Citro, S., Mattoscio, D., Pisati, F., Moser, M.A., Visintin, R., Seiser, C., Chiocca, S. (2016) Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development. Scientific Reports. 6:30213
- Bergeron, S.A., Carrier, N., Li, G.H., Ahn, S., Burgess, H.A. (2015) Gsx1 expression defines neurons required for prepulse inhibition. Molecular psychiatry. 20(8):974-85
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Satou, C., Kimura, Y., Hirata, H., Suster, M.L., Kawakami, K., and Higashijima, S. (2013) Transgenic tools to characterize neuronal properties of discrete populations of zebrafish neurons. Development (Cambridge, England). 140(18):3927-3931
- Filippi, A., Jainok, C., and Driever, W. (2012) Analysis of transcriptional codes for zebrafish dopaminergic neurons reveals essential functions of Arx and Isl1 in prethalamic dopaminergic neuron development. Developmental Biology. 369(1):133-149
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