Gene
saa
- ID
- ZDB-GENE-040927-15
- Name
- serum amyloid A
- Symbol
- saa Nomenclature History
- Previous Names
-
- zgc:103580
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Acts upstream of with a positive effect on neutrophil chemotaxis. Acts upstream of with a negative effect on neutrophil-mediated killing of bacterium. Acts upstream of or within with a positive effect on cell maturation. Acts upstream of or within neutrophil migration and response to bacterium. Predicted to be located in extracellular region. Predicted to be part of high-density lipoprotein particle. Is expressed in liver. Orthologous to several human genes including SAA1 (serum amyloid A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Murdoch et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-saa | (2) | |
| MO1-saa | N/A | Kanther et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000096 | Serum amyloid A protein |
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Domain Details Per Protein
| Protein | Length | Serum amyloid A protein |
|---|---|---|
|
UniProtKB:Q642J9
|
121 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-0.349cldn15la:saa,myl7:mCherry) |
|
| 3 | Murdoch et al., 2019 | |
| Tg(-2.8fabp10a:saa,myl7:EGFP) |
|
| 1 | Murdoch et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | cDNA | MGC:103580 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192097 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001005599 (1) | 654 nt | ||
| Genomic | GenBank:FO704739 (1) | 34724 nt | ||
| Polypeptide | UniProtKB:Q642J9 (1) | 121 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | SAA1 | 11 | Amino acid sequence comparison (2) |
- Gaillard, A.L., Mohamad, T., Quan, F.B., de Cian, A., Mosimann, C., Tostivint, H., Pézeron, G. (2023) Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Developmental Biology. 496:36-51
- Ni, Y., Zhang, Y., Zheng, L., Rong, N., Yang, Y., Gong, P., Yang, Y., Siwu, X., Zhang, C., Zhu, L., Fu, Z. (2023) Bifidobacterium and Lactobacillus improve inflammatory bowel disease in zebrafish of different ages by regulating the intestinal mucosal barrier and microbiota. Life sciences. 324:121699
- Sun, S.X., Liu, Y.C., Limbu, S.M., Li, D.L., Chen, L.Q., Zhang, M.L., Yin, Z., Du, Z.Y. (2023) Vitellogenin 1 is essential for fish reproduction by transporting DHA-containing phosphatidylcholine from liver to ovary. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(4):159289
- Di Chiacchio, I.M., Gómez-Abenza, E., Paiva, I.M., de Abreu, D.J.M., Rodríguez-Vidal, J.F., Carvalho, E.E.N., Carvalho, S.M., Solis-Murgas, L.D., Mulero, V. (2022) Bee pollen in zebrafish diet affects intestinal microbiota composition and skin cutaneous melanoma development. Scientific Reports. 12:9998
- Ma, J., Shao, X., Geng, F., Liang, S., Yu, C., Zhang, R. (2022) Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress. iScience. 25:104957
- Moreno Traspas, R., Teoh, T.S., Wong, P.M., Maier, M., Chia, C.Y., Lay, K., Ali, N.A., Larson, A., Al Mutairi, F., Al-Sannaa, N.A., Faqeih, E.A., Alfadhel, M., Cheema, H.A., Dupont, J., Bézieau, S., Isidor, B., Low, D.Y., Wang, Y., Tan, G., Lai, P.S., Piloquet, H., Joubert, M., Kayserili, H., Kripps, K.A., Nahas, S.A., Wartchow, E.P., Warren, M., Bhavani, G.S., Dasouki, M., Sandoval, R., Carvalho, E., Ramos, L., Porta, G., Wu, B., Lashkari, H.P., AlSaleem, B., BaAbbad, R.M., Abreu Ferrão, A.N., Karageorgou, V., Ordonez-Herrera, N., Khan, S., Bauer, P., Cogne, B., Bertoli-Avella, A.M., Vincent, M., Girisha, K.M., Reversade, B. (2022) Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis. Nature Genetics. 54(8):1214-1226
- Shin, K., Begeman, I.J., Cao, J., Kang, J. (2022) leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(1):91-106
- Sun, J., Peterson, E.A., Wang, A.Z., Ou, J., Smith, K.E., Poss, K.D., Wang, J. (2022) hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration. Circulation. 146(1):48-63
- Lai, C.Y., Yeh, K.Y., Lin, C.Y., Hsieh, Y.W., Lai, H.H., Chen, J.R., Hsu, C.C., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling. Cancers. 13(5):
- Shimizu, T., Fujita, N., Tsuji-Tamura, K., Kitagawa, Y., Fujisawa, T., Tamura, M., Sato, M. (2021) Osteocytes as main responders to low-intensity pulsed ultrasound treatment during fracture healing. Scientific Reports. 11:10298
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