Gene
lingo1b
- ID
- ZDB-GENE-040912-136
- Name
- leucine rich repeat and Ig domain containing 1b
- Symbol
- lingo1b Nomenclature History
- Previous Names
-
- lingo1
- zgc:92338 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Involved in myelination and neuron development. Predicted to localize to extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in glaucoma. Is expressed in basal plate midbrain region; nervous system; neural plate; presumptive diencephalon; and presumptive telencephalon. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d0317 (25 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Yin et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 64 | Alliance | Intellectual developmental disorder, autosomal recessive 64 | 618103 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Family | IPR050541 | Leucine-rich repeat and transmembrane domain-containing protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
| Repeat | IPR026906 | BspA-type LRR region |
Domain Details Per Protein
| Protein | Length | BspA-type LRR region | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Leucine-rich repeat | Leucine-rich repeat and transmembrane domain-containing protein | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q66HV9
|
622 | ||||||||||||
|
UniProtKB:A0A8M2BE21
|
621 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lingo1b-201
(1)
|
Ensembl | 3,128 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| ab1-lingo1b | polyclonal | Rabbit |
|
1 |
Plasmids
No data available