Gene
sars1
- ID
- ZDB-GENE-040831-1
- Name
- seryl-tRNA synthetase 1
- Symbol
- sars1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables serine-tRNA ligase activity. Involved in negative regulation of sprouting angiogenesis; negative regulation of vascular endothelial growth factor production; and seryl-tRNA aminoacylation. Acts upstream of or within branching involved in blood vessel morphogenesis; cerebellum vasculature development; and regulation of angiogenesis. Located in nucleus. Is expressed in several structures, including alar plate midbrain region; immature eye; liver; midbrain; and musculature system. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908380 (8 images)
- IMAGE:7155143 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi3817Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| ko095 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| la022685Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| s228 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| s277 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa382 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa3234 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with microcephaly, ataxia, and seizures | 617709 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| arteriovenous malformations of the brain | pku6Tg + MO1-sars1 | standard conditions | Wang et al., 2018 |
| arteriovenous malformations of the brain | pku6Tg + MO4-sars1 | standard conditions | Wang et al., 2018 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002314 | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Domain | IPR015866 | Serine-tRNA synthetase, type1, N-terminal |
| Domain | IPR033729 | Serine-tRNA ligase catalytic core domain |
| Family | IPR002317 | Serine-tRNA ligase, type1 |
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Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Serine-tRNA ligase catalytic core domain | Serine-tRNA ligase, type1 | Serine-tRNA synthetase, type1, N-terminal | Serine-tRNA synthetase, type1, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DRC0
|
515 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-207E14 | ZFIN Curated Data | |
| Encodes | EST | fk51f08 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6908380 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7155143 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92152 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003882 (1) | 2286 nt | ||
| Genomic | GenBank:AL954678 (1) | 219500 nt | ||
| Polypeptide | UniProtKB:Q6DRC0 (1) | 515 aa |
- Giong, H.K., Lee, J.S. (2021) Systematic expression profiling of neuropathy-related aminoacyl-tRNA synthetases in zebrafish during development. Biochemical and Biophysical Research Communications. 587:92-98
- Zhang, F., Zeng, Q.Y., Xu, H., Xu, A.N., Liu, D.J., Li, N.Z., Chen, Y., Jin, Y., Xu, C.H., Feng, C.Z., Zhang, Y.L., Liu, D., Liu, N., Xie, Y.Y., Yu, S.H., Yuan, H., Xue, K., Shi, J.Y., Liu, T.X., Xu, P.F., Zhao, W.L., Zhou, Y., Wang, L., Huang, Q.H., Chen, Z., Chen, S.J., Zhou, X.L., Sun, X.J. (2021) Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis. Cell discovery. 7:98
- Shi, Y., Liu, Z., Zhang, Q., Vallee, I., Mo, Z., Kishi, S., Yang, X.L. (2020) Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis. PLoS Biology. 18:e3000991
- Zhang, X., Zou, G., Li, X., Wang, L., Xie, T., Zhao, J., Wang, L., Jiao, S., Xiang, R., Ye, H., Shi, Y. (2020) An isoflavone derivative potently inhibits the angiogenesis and progression of triple-negative breast cancer by targeting the MTA2/SerRS/VEGFA pathway. Journal fur Ornithologie. 17:693-706
- Zou, G., Zhang, X., Wang, L., Li, X., Xie, T., Zhao, J., Yan, J., Wang, L., Ye, H., Jiao, S., Xiang, R., Shi, Y. (2020) Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription. Theranostics. 10:6839-6853
- Wang, K., Zhao, S., Liu, B., Zhang, Q., Li, Y., Liu, J., Shen, Y., Ding, X., Lin, J., Wu, Y., Yan, Z., Chen, J., Li, X., Song, X., Niu, Y., Liu, J., Chen, W., Ming, Y., Du, R., Chen, C., Long, B., Zhang, Y., Tong, X., Zhang, S., Posey, J.E., Zhang, B., Wu, Z., Wythe, J.D., Liu, P., Lupski, J.R., Yang, X., Wu, N. (2018) Perturbations of BMP/TGF-β and VEGF/VEGFR signalling pathways in non-syndromic sporadic brain arteriovenous malformations (BAVM). Journal of Medical Genetics. 55(10):675-684
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Fu, C.Y., Wang, P.C., Tsai, H.J. (2017) Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis. Nucleic acids research. 45:2423-2437
- Waldron, A.L., Cahan, S.H., Franklyn, C.S., Ebert, A.M. (2017) A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases. PLoS One. 12:e0185317
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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