Gene

aurka

ID

ZDB-GENE-040801-161

Name

aurora kinase A

Symbol

aurka Nomenclature History

Previous Names

fb37c10
fc02c02
wu:fb37c10
wu:fc02c02
zgc:100912

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have histone serine kinase activity. Involved in mitotic cell cycle. Predicted to localize to condensed nuclear chromosome, centromeric region and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Is expressed in several structures, including caudal fin; immature eye; nervous system; somite; and spinal cord neural tube. Orthologous to human AURKA (aurora kinase A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Jeon et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With aurka Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
colorectal cancer	Alliance	{Colon cancer, susceptibility to}	114500

Associated With aurka Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR030611	Aurora kinase A
Family	IPR030616	Aurora kinase-like
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily