Gene
hbbe2
- ID
- ZDB-GENE-040702-1
- Name
- hemoglobin beta embryonic-2
- Symbol
- hbbe2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Predicted to be involved in hydrogen peroxide catabolic process. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in hematopoietic cell; hematopoietic system; posterior lateral plate mesoderm; and vasculature. Human ortholog(s) of this gene implicated in sickle cell anemia. Orthologous to human HBE1 (hemoglobin subunit epsilon 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Globin | Globin-like superfamily | Globin/Protoglobin | Hemoglobin and related oxygen transporters | Hemoglobin, beta-type |
|---|---|---|---|---|---|---|
|
UniProtKB:Q7T1B0
|
147 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218L14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162555 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212846 (1) | 532 nt | ||
| Genomic | GenBank:CR352324 (1) | 206894 nt | ||
| Polypeptide | UniProtKB:Q7T1B0 (1) | 147 aa |
No data available
- Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014
- Prykhozhij, S.V., Ban, K., Brown, Z.L., Kobar, K., Wajnberg, G., Fuller, C., Chacko, S., Lacroix, J., Crapoulet, N., Midgen, C., Shlien, A., Malkin, D., Berman, J.N. (2024) miR-34a is a tumor suppressor in zebrafish and its expression levels impact metabolism, hematopoiesis and DNA damage. PLoS Genetics. 20:e1011290e1011290
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
- Mao, A., Li, Z., Ning, G., Zhou, Z., Wei, C., Li, J., He, X., Wang, Q. (2023) Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis. Development (Cambridge, England). 150(22):
- Chen, X., Qiu, T., Pan, M., Xiao, P., Li, W. (2022) Fluxapyroxad disrupt erythropoiesis in zebrafish (Danio rerio) embryos. Ecotoxicology and environmental safety. 247:114259
- Dai, Y., Wu, S., Cao, C., Xue, R., Luo, X., Wen, Z., Xu, J. (2022) Csf1rb regulates definitive hematopoiesis in zebrafish. Development (Cambridge, England). 149(16)
- Dong, H., Mao, L., Bai, C., Ye, K., Wu, H., Lei, Y., Yu, S., Liu, Y., Tao, J., Pan, W., Xu, H., Lin, J., Zhu, J., Dong, Q. (2022) Characterization of Developmental Neurobehavioral Toxicity in a Zebrafish MPTP-Induced Model: A Novel Mechanism Involving Anemia. ACS Chemical Neuroscience. 13(13):1877-1890
- Bao, B., An, W., Lu, Q., Wang, Y., Lu, Z., Tu, J., Zhang, H., Duan, Y., Yuan, W., Zhu, X., Jia, H. (2021) Sfxn1 is essential for erythrocyte maturation via facilitating hemoglobin production in zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1867(5):166096
- Chen, X., Li, W. (2021) Isoflucypram cardiovascular toxicity in zebrafish (Danio rerio). The Science of the total environment. 787:147529
- Weinreb, J.T., Gupta, V., Sharvit, E., Weil, R., Bowman, T.V. (2021) Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish. Haematologica. 107(3):644-654
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