Gene

lum

ID

ZDB-GENE-040625-24

Name

lumican

Symbol

lum Nomenclature History

Previous Names

lumican (1)
zgc:86661 (1)
zlum (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Involved in collagen fibril organization and embryonic camera-type eye morphogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in carotid artery disease; coronary artery disease; and pancreatic cancer. Is expressed in several structures, including digestive system; epidermis; head mesenchyme; heart; and nervous system. Orthologous to human LUM (lumican).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7145913 (1 image)
IMAGE:6904895 (23 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lum Human Ortholog

No data available

Associated With lum Via Experimental Models

Human Disease	Fish	Conditions	Citations
myopia	AB/TU + MO1-lum	standard conditions	Lin et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000372	Leucine-rich repeat N-terminal domain
Family	IPR050333	Small Leucine-Rich Proteoglycans
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype