Gene
rpl11
- ID
- ZDB-GENE-040625-147
- Name
- ribosomal protein L11
- Symbol
- rpl11 Nomenclature History
- Previous Names
-
- zgc:86748
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within several processes, including erythrocyte development; glucose homeostasis; and hemoglobin biosynthetic process. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in endodermal cell; eye; intestine; liver; and pancreas. Used to study Diamond-Blackfan anemia. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 7 and T-cell acute lymphoblastic leukemia. Orthologous to human RPL11 (ribosomal protein L11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 37 figures from 16 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diamond-Blackfan anemia 7 | Alliance | Diamond-Blackfan anemia 7 | 612562 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Diamond-Blackfan anemia | WT + MO1-rpl11 | standard conditions | (3) |
| Diamond-Blackfan anemia | rpl11hi3820bTg/hi3820bTg | standard conditions | (2) |
| Diamond-Blackfan anemia | rpl11hi3820bTg/hi3820bTg | standard conditions | (3) |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020929 | Large ribosomal subunit protein uL5, conserved site |
| Domain | IPR031309 | Large ribosomal subunit protein uL5, C-terminal |
| Domain | IPR031310 | Large ribosomal subunit protein uL5, N-terminal |
| Family | IPR002132 | Large ribosomal subunit protein uL5 |
| Homologous_superfamily | IPR022803 | Large ribosomal subunit protein uL5 domain superfamily |
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Domain Details Per Protein
| Protein | Length | Large ribosomal subunit protein uL5 | Large ribosomal subunit protein uL5, conserved site | Large ribosomal subunit protein uL5, C-terminal | Large ribosomal subunit protein uL5 domain superfamily | Large ribosomal subunit protein uL5, N-terminal |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6IQI6
|
178 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | cDNA | MGC:86748 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002139 (1) | 691 nt | ||
| Genomic | GenBank:CABZ01086825 (1) | 24786 nt | ||
| Polypeptide | UniProtKB:Q6IQI6 (1) | 178 aa |
- Flentke, G.R., Wilkie, T.E., Baulch, J., Huang, Y., Smith, S.M. (2024) Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells. PLoS One. 19:e0304557e0304557
- Song, G., Feng, G., Li, Q., Peng, J., Ge, W., Long, Y., Cui, Z. (2024) Transcriptomic Characterization of Key Factors and Signaling Pathways for the Regeneration of Partially Hepatectomized Liver in Zebrafish. International Journal of Molecular Sciences. 25(13):
- Chen, C., Huang, H., Yan, R., Lin, S., Qin, W. (2019) Loss of rps9 in Zebrafish Leads to p53-Dependent Anemia. G3 (Bethesda). 9(12):4149-4157
- Calo, E., Gu, B., Bowen, M.E., Aryan, F., Zalc, A., Liang, J., Flynn, R.A., Swigut, T., Chang, H.Y., Attardi, L.D., Wysocka, J. (2018) Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature. 554:112-117
- Danilova, N., Wilkes, M., Bibikova, E., Youn, M.Y., Sakamoto, K.M., Lin, S. (2018) Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. Scientific Reports. 8:5165
- Rovira, M., Borràs, D.M., Marques, I.J., Puig, C., Planas, J.V. (2018) Physiological Responses to Swimming-Induced Exercise in the Adult Zebrafish Regenerating Heart. Frontiers in Physiology. 9:1362
- Sabharwal, A., Sharma, D., Vellarikkal, S.K., Jayarajan, R., Verma, A., Senthivel, V., Scaria, V., Sivasubbu, S. (2018) Organellar transcriptome sequencing reveals mitochondrial localization of nuclear encoded transcripts. Mitochondrion. 46:59-68
- Sorrells, S., Nik, S., Casey, M., Cameron, R.C., Truong, H., Toruno, C., Gulfo, M., Lowe, A., Jette, C., Stewart, R.A., Bowman, T.V. (2018) Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis. Disease models & mechanisms. 11(2)
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Berres, M.E., Garic, A., Flentke, G.R., Smith, S.M. (2017) Transcriptome Profiling Identifies Ribosome Biogenesis as a Target of Alcohol Teratogenicity and Vulnerability during Early Embryogenesis. PLoS One. 12:e0169351
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