Gene
tubg1
- ID
- ZDB-GENE-040426-836
- Name
- tubulin, gamma 1
- Symbol
- tubg1 Nomenclature History
- Previous Names
-
- tubgl (1)
- zgc:55894
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic sister chromatid segregation. Predicted to act upstream of or within cytoplasmic microtubule organization. Predicted to be located in cytoskeleton. Predicted to be part of gamma-tubulin complex. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in blastomere; oocyte stage III; and oocyte stage V. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to several human genes including TUBG1 (tubulin gamma 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145281 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| complex cortical dysplasia with other brain malformations 4 | Alliance | Cortical dysplasia, complex, with other brain malformations 4 | 615412 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017975 | Tubulin, conserved site |
| Domain | IPR003008 | Tubulin/FtsZ, GTPase domain |
| Domain | IPR018316 | Tubulin/FtsZ, 2-layer sandwich domain |
| Family | IPR000217 | Tubulin |
| Family | IPR002454 | Gamma tubulin |
| Homologous_superfamily | IPR008280 | Tubulin/FtsZ, C-terminal |
| Homologous_superfamily | IPR023123 | Tubulin, C-terminal |
| Homologous_superfamily | IPR036525 | Tubulin/FtsZ, GTPase domain superfamily |
| Homologous_superfamily | IPR037103 | Tubulin/FtsZ-like, C-terminal domain |
Domain Details Per Protein
| Protein | Length | Gamma tubulin | Tubulin | Tubulin, conserved site | Tubulin, C-terminal | Tubulin/FtsZ, 2-layer sandwich domain | Tubulin/FtsZ, C-terminal | Tubulin/FtsZ, GTPase domain | Tubulin/FtsZ, GTPase domain superfamily | Tubulin/FtsZ-like, C-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B0JZL0
|
264 | |||||||||
|
UniProtKB:A0A8M6YXT8
|
261 | |||||||||
|
UniProtKB:Q7ZVM5
|
451 |
Interactions and Pathways
No data available
Plasmids
No data available