Gene

hdac8

ID

ZDB-GENE-040426-2772

Name

histone deacetylase 8

Symbol

hdac8 Nomenclature History

Previous Names

wu:fd19a02
zgc:66196 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have histone deacetylase activity. Predicted to be involved in histone H3 deacetylation; histone H4 deacetylation; and positive regulation of transcription by RNA polymerase II. Predicted to localize to histone deacetylase complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7144626 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hdac8 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Cornelia de Lange syndrome 5	Alliance	Cornelia de Lange syndrome 5	300882

Associated With hdac8 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Cornelia de Lange syndrome	AB + MO2-hdac8	standard conditions	Bottai et al., 2018
Cornelia de Lange syndrome	AB + MO3-hdac8	standard conditions	Bottai et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011613	GH15-like domain
Domain	IPR023801	Histone deacetylase domain
Domain	IPR045583	Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain
Family	IPR000286	Histone deacetylase family
Family	IPR003084	Histone deacetylase
Family	IPR008734	Phosphorylase kinase alpha/beta subunit
Family	IPR050284	Histone deacetylase and polyamine deacetylase
Homologous_superfamily	IPR008928	Six-hairpin glycosidase superfamily
Homologous_superfamily	IPR012341	Six-hairpin glycosidase-like superfamily
Homologous_superfamily	IPR023696	Ureohydrolase domain superfamily
Homologous_superfamily	IPR037138	Histone deacetylase domain superfamily

Domain Details Per Protein

Protein	Length	GH15-like domain	Histone deacetylase	Histone deacetylase and polyamine deacetylase	Histone deacetylase domain	Histone deacetylase domain superfamily	Histone deacetylase family	Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain	Phosphorylase kinase alpha/beta subunit	Six-hairpin glycosidase-like superfamily	Six-hairpin glycosidase superfamily	Ureohydrolase domain superfamily
UniProtKB:Q7SXM0 InterPro	378
UniProtKB:A0A8M2BE34 InterPro	311
UniProtKB:A0A286YAZ5 InterPro	1232
UniProtKB:E7F4R5 InterPro	1219

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	hdac8-205 (1) Ensembl	Ensembl	566 nt	Select Tool
mRNA	hdac8-201 (1) Ensembl	Ensembl	1,935 nt	Select Tool
mRNA	hdac8-203 (1) Ensembl	Ensembl	725 nt	Select Tool
ncRNA	hdac8-002 (1) Ensembl	Ensembl	475 nt	Select Tool
ncRNA	hdac8-004 (1) Ensembl	Ensembl	528 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-hdac8	polyclonal	hdac8	IgG	Rabbit	WB	Santa Cruz Biotechnology, Inc.	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations