Gene
cdk2
- ID
- ZDB-GENE-040426-2741
- Name
- cyclin dependent kinase 2
- Symbol
- cdk2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; protein phosphorylation; and regulation of G2/M transition of mitotic cell cycle. Predicted to act upstream of or within phosphorylation. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in nervous system and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56598 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Yang et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cdk2 | (2) | |
| CRISPR2-cdk2 | Wang et al., 2021 | |
| CRISPR3-cdk2 | Wang et al., 2021 | |
| MO1-cdk2 | N/A | Yang et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050108 | Cyclin-dependent kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Length | Cyclin-dependent kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZWB1
|
298 |
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Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-182B19 | ZFIN Curated Data | |
| Encodes | EST | fa10c02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56598 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77684 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213406 (1) | 1619 nt | ||
| Genomic | GenBank:CU633767 (2) | 38548 nt | ||
| Polypeptide | UniProtKB:Q7ZWB1 (1) | 298 aa |
- Katkat, E., Demirci, Y., Heger, G., Karagulle, D., Papatheodorou, I., Brazma, A., Ozhan, G. (2023) Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration but suppress invasiveness, migration, and proliferation of melanoma cells. Frontiers in cell and developmental biology. 11:12979101297910
- Cao, L., Fang, H., Yan, D., Wu, X.M., Zhang, J., Chang, M.X. (2022) CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. 5:889
- Hou, C.Y., Ma, C.Y., Lin, Y.J., Huang, C.L., Wang, H.D., Yuh, C.H. (2022) WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy. International Journal of Molecular Sciences. 23(20):
- Tu, J., Yu, S., Li, J., Ren, M., Zhang, Y., Luo, J., Sun, K., Lv, Y., Han, Y., Huang, Y., Ren, X., Jiang, T., Tang, Z., Williams, M.T.S., Lu, Q., Liu, M. (2022) Dhx38 regulates the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Development (Cambridge, England). 149(17)
- Wang, W., Li, H., Huang, M., Wang, X., Li, W., Qian, X., Jing, L. (2022) Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance. Open Biology. 12:220172
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
- Lee, J.Y., Park, H., Lim, W., Song, G. (2021) Aclonifen causes developmental abnormalities in zebrafish embryos through mitochondrial dysfunction and oxidative stress. The Science of the total environment. 771:145445
- Lee, J.Y., Park, H., Lim, W., Song, G. (2021) Benfuresate induces developmental toxicity in zebrafish larvae by generating apoptosis and pathological modifications. Pesticide biochemistry and physiology. 172:104751
- Ma, J., Huang, Y., Peng, Y., Xu, Z., Wang, Z., Chen, X., Xie, S., Jiang, P., Zhong, K., Lu, H. (2021) Bifenazate exposure induces cardiotoxicity in zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 274:116539
- Wang, Y., Hsu, A.Y., Walton, E.M., Park, S.J., Syahirah, R., Wang, T., Zhou, W., Ding, C., Lemke, A.P., Zhang, G., Tobin, D.M., Deng, Q. (2021) A robust and flexible CRISPR/Cas9 based system for neutrophil-specific gene inactivation in zebrafish. Journal of Cell Science. 134(8):
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