Gene

clic5b

ID

ZDB-GENE-040426-2542

Name

chloride intracellular channel 5b

Symbol

clic5b Nomenclature History

Previous Names

clic5
clic5a (1)
im:6907594
zgc:77538

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have chloride channel activity and voltage-gated ion channel activity. Predicted to be involved in chloride transport; regulation of ion transmembrane transport; and sensory perception of sound. Predicted to localize to chloride channel complex and cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 103. Is expressed in digestive system; immature eye; pronephric duct; and sensory system. Orthologous to human CLIC5 (chloride intracellular channel 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6907594 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Ott et al., 2023
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With clic5b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 103	Alliance	?Deafness, autosomal recessive 103	616042

Associated With clic5b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR010987	Glutathione S-transferase, C-terminal-like
Domain	IPR042069	CLIC5, C-terminal GST domain
Domain	IPR053823	CLIC, N-terminal domain
Family	IPR002946	Intracellular chloride channel
Family	IPR040079	Glutathione transferase family
Homologous_superfamily	IPR036249	Thioredoxin-like superfamily
Homologous_superfamily	IPR036282	Glutathione S-transferase, C-terminal domain superfamily