Gene
elmo1
- ID
- ZDB-GENE-040426-2069
- Name
- engulfment and cell motility 1 (ced-12 homolog, C. elegans)
- Symbol
- elmo1 Nomenclature History
- Previous Names
-
- im:7151147
- wu:fq24e08
- zgc:85612 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable SH3 domain binding activity. Acts upstream of or within cilium assembly; lymphangiogenesis; and positive regulation of angiogenesis. Predicted to be located in cytoplasm. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blood vessel; immature eye; mesoderm; nervous system; and pronephric tubule. Orthologous to human ELMO1 (engulfment and cell motility 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7147174 (1 image)
- IMAGE:7151147 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 24 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| kbc1 | Allele with one delins | Unknown | Unknown | CRISPR | |
| la028049Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028050Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa23561 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa23562 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| szy103 | Allele with one deletion | Unknown | Unknown | TALEN | |
| um92 | Allele with one delins | Unknown | Frameshift, Premature Stop | zinc finger nuclease | |
| zf3695 | Allele with one insertion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Armadillo-like helical | Armadillo-type fold | ELMO, armadillo-like helical domain | ELMO domain | Engulfment and cell motility domain-containing protein | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YUG7
|
521 | |||||||
|
UniProtKB:A0A8M3ASM6
|
714 | |||||||
|
UniProtKB:A0A2R8RS12
|
728 | |||||||
|
UniProtKB:Q6NV39
|
726 | |||||||
|
UniProtKB:A0A8M3AVM1
|
247 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-elmo1 | polyclonal | Goat |
|
Everest Biotech
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-302O18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-125F15 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-283J24 | ZFIN Curated Data | |
| Encodes | EST | fq24e08 | Rauch et al., 2003 | |
| Encodes | EST | IMAGE:7147174 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7151147 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:85612 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213091 (1) | 3396 nt | ||
| Genomic | GenBank:CU571256 (1) | 144622 nt | ||
| Polypeptide | UniProtKB:A0A8M3ASM3 (1) | 740 aa |
- Boger, M., Bennewitz, K., Wohlfart, D.P., Hausser, I., Sticht, C., Poschet, G., Kroll, J. (2022) Comparative Morphological, Metabolic and Transcriptome Analyses in elmo1-/- , elmo2-/- , and elmo3-/- Zebrafish Mutants Identified a Functional Non-Redundancy of the Elmo Proteins. Frontiers in cell and developmental biology. 10:918529
- Wright, K., de Silva, K., Plain, K.M., Purdie, A.C., Blair, T.A., Duggin, I.G., Britton, W.J., Oehlers, S.H. (2021) Mycobacterial infection-induced miR-206 inhibits protective neutrophil recruitment via the CXCL12/CXCR4 signalling axis. PLoS pathogens. 17:e1009186
- Xue, R., Wang, Y., Wang, T., Lyu, M., Mo, G., Fan, X., Li, J., Yen, K., Yu, S., Liu, Q., Xu, J. (2021) Functional Verification of Novel ELMO1 Variants by Live Imaging in Zebrafish. Frontiers in cell and developmental biology. 9:723804
- Kedra, M., Banasiak, K., Kisielewska, K., Wolinska-Niziol, L., Jaworski, J., Zmorzynska, J. (2020) TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex. Proceedings of the National Academy of Sciences of the United States of America. 117(4):2170-2179
- Kuil, L.E., Oosterhof, N., Ferrero, G., Mikulášová, T., Hason, M., Dekker, J., Rovira, M., van der Linde, H.C., van Strien, P.M., de Pater, E., Schaaf, G., Bindels, E.M., Wittamer, V., van Ham, T.J. (2020) Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. eLIFE. 9:
- Mikdache, A., Fontenas, L., Albadri, S., Revenu, C., Loisel-Duwattez, J., Lesport, E., Degerny, C., Del Bene, F., Tawk, M. (2019) Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish. Cellular and molecular life sciences : CMLS. 77(1):161-177
- Zhu, Y., Crowley, S.C., Latimer, A.J., Lewis, G.M., Nash, R., Kucenas, S. (2019) Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System. Cell. 179(1):74-89.e10
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Cetinkaya, A., Xiong, J.R., Vargel, İ., Kösemehmetoğlu, K., Canter, H.İ., Gerdan, Ö.F., Longo, N., Alzahrani, A., Camps, M.P., Taskiran, E.Z., Laupheimer, S., Botto, L.D., Paramalingam, E., Gormez, Z., Uz, E., Yuksel, B., Ruacan, Ş., Sağıroğlu, M.Ş., Takahashi, T., Reversade, B., Akarsu, N.A. (2016) Loss-of-Function Mutations in ELMO2 Cause Intraosseous Vascular Malformation by Impeding RAC1 Signaling. American journal of human genetics. 99(2):299-317
- Sharma, K.R., Heckler, K., Stoll, S.J., Hillebrands, J.L., Kynast, K., Herpel, E., Porubsky, S., Elger, M., Hadaschik, B., Bieback, K., Hammes, H.P., Nawroth, P.P., Kroll, J. (2016) ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions. Scientific Reports. 6:37172
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