Gene
elmo1
- ID
- ZDB-GENE-040426-2069
- Name
- engulfment and cell motility 1 (ced-12 homolog, C. elegans)
- Symbol
- elmo1 Nomenclature History
- Previous Names
-
- im:7151147
- wu:fq24e08
- zgc:85612 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable SH3 domain binding activity. Acts upstream of or within cilium assembly; lymphangiogenesis; and positive regulation of angiogenesis. Predicted to be located in cytoplasm. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blood vessel; immature eye; mesoderm; nervous system; and pronephric tubule. Orthologous to human ELMO1 (engulfment and cell motility 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7147174 (1 image)
- IMAGE:7151147 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 24 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR006816 | ELMO domain |
| Domain | IPR024574 | ELMO, armadillo-like helical domain |
| Family | IPR050868 | Engulfment and cell motility domain-containing protein |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
Domain Details Per Protein
| Protein | Length | Armadillo-like helical | Armadillo-type fold | ELMO, armadillo-like helical domain | ELMO domain | Engulfment and cell motility domain-containing protein | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YUG7
|
521 | |||||||
|
UniProtKB:A0A8M3ASM6
|
714 | |||||||
|
UniProtKB:A0A2R8RS12
|
728 | |||||||
|
UniProtKB:Q6NV39
|
726 | |||||||
|
UniProtKB:A0A8M3AVM1
|
247 | |||||||
|
UniProtKB:A0A8M3ASM3
|
740 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-elmo1 | polyclonal | Goat |
|
Everest Biotech
|
2 |
Plasmids
No data available