Gene
spo11
- ID
- ZDB-GENE-040426-1900
- Name
- SPO11 initiator of meiotic double stranded breaks
- Symbol
- spo11 Nomenclature History
- Previous Names
-
- zgc:77876 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity. Acts upstream of or within chromosome organization involved in meiotic cell cycle. Predicted to be located in chromosome. Predicted to be active in nuclear chromosome. Orthologous to human SPO11 (SPO11 initiator of meiotic double stranded breaks).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77876 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-spo11 | Takemoto et al., 2020 | |
| TALEN1-spo11 | (3) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013049 | Spo11/DNA topoisomerase VI, subunit A, N-terminal |
| Domain | IPR034136 | Topoisomerase 6 subunit A/Spo11, TOPRIM domain |
| Family | IPR002815 | Spo11/DNA topoisomerase VI subunit A |
| Family | IPR013048 | Meiotic recombination, Spo11 |
| Homologous_superfamily | IPR036078 | Spo11/DNA topoisomerase VI subunit A superfamily |
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Domain Details Per Protein
| Protein | Length | Meiotic recombination, Spo11 | Spo11/DNA topoisomerase VI subunit A | Spo11/DNA topoisomerase VI, subunit A, N-terminal | Spo11/DNA topoisomerase VI subunit A superfamily | Topoisomerase 6 subunit A/Spo11, TOPRIM domain | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6P0S6
|
383 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-152J3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77876 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192913 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205682 (1) | 1588 nt | ||
| Genomic | GenBank:CR339064 (1) | 98209 nt | ||
| Polypeptide | UniProtKB:Q6P0S6 (1) | 383 aa |
- Ou, Y., Li, H., Li, J., Dai, X., He, J., Wang, S., Liu, Q., Yang, C., Wang, J., Zhao, R., Yin, Z., Shu, Y., Liu, S. (2024) Formation of different polyploids through disrupting meiotic crossover frequencies based on cntd1 knockout in zebrafish. Molecular Biology and Evolution. 41(3):
- Wilson, M.L., Romano, S.N., Khatri, N., Aharon, D., Liu, Y., Kaufman, O.H., Draper, B.W., Marlow, F.L. (2024) Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios. Nature communications. 15:52485248
- Blokhina, Y.P., Frees, M.A., Nguyen, A., Sharifi, M., Chu, D.B., Bispo, K., Olaya, I., Draper, B.W., Burgess, S.M. (2021) Rad21l1 cohesin subunit is dispensable for spermatogenesis but not oogenesis in zebrafish. PLoS Genetics. 17:e1009127
- Dai, X., Cheng, X., Huang, J., Gao, Y., Wang, D., Feng, Z., Zhai, G., Lou, Q., He, J., Wang, Z., Yin, Z. (2021) Rbm46, a novel germ cell specific factor, modulates meiotic progression and spermatogenesis. Biology of reproduction. 104(5):1139-1153
- Imai, Y., Saito, K., Takemoto, K., Velilla, F., Kawasaki, T., Ishiguro, K.I., Sakai, N. (2021) Sycp1 Is Not Required for Subtelomeric DNA Double-Strand Breaks but Is Required for Homologous Alignment in Zebrafish Spermatocytes. Frontiers in cell and developmental biology. 9:664377
- Peng, L., Fu, W., Wu, X., He, S., Zhao, H., Liu, J., Liu, W., Xiao, Y. (2020) Bisexual Fertile Triploid Zebrafish (Danio rerio): a Rare Case. Marine biotechnology (New York, N.Y.). 22(3):443-455
- Takemoto, K., Imai, Y., Saito, K., Kawasaki, T., Carlton, P.M., Ishiguro, K.I., Sakai, N. (2020) Sycp2 is essential for synaptonemal complex assembly, early meiotic recombination and homologous pairing in zebrafish spermatocytes. PLoS Genetics. 16:e1008640
- Blokhina, Y.P., Nguyen, A.D., Draper, B.W., Burgess, S.M. (2019) The telomere bouquet is a hub where meiotic double-strand breaks, synapsis, and stable homolog juxtaposition are coordinated in the zebrafish, Danio rerio. PLoS Genetics. 15:e1007730
- Crespo, D., Assis, L.H.C., van de Kant, H.J.G., de Waard, S., Safian, D., Lemos, M.S., Bogerd, J., Schulz, R.W. (2019) Endocrine and local signaling interact to regulate spermatogenesis in zebrafish: Follicle-stimulating hormone, retinoic acid and androgens. Development (Cambridge, England). 146(21):
- Wang, Y.Q., Li, Y.W., Chen, Q.L., Liu, Z.H. (2018) Long-term exposure of xenoestrogens with environmental relevant concentrations disrupted spermatogenesis of zebrafish through altering sex hormone balance, stimulating germ cell proliferation, meiosis and enhancing apoptosis. Environmental pollution (Barking, Essex : 1987). 244:486-494
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