Gene

cadm2a

ID

ZDB-GENE-040426-1614

Name

cell adhesion molecule 2a

Symbol

cadm2a Nomenclature History

Previous Names

igsf4d (1)
zgc:66339 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Is expressed in immature eye; nervous system; and pancreatic system. Human ortholog(s) of this gene implicated in autism spectrum disorder; malignant astrocytoma; obesity; psoriasis; and type 2 diabetes mellitus. Orthologous to human CADM2 (cell adhesion molecule 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66339 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cadm2a Human Ortholog

No data available

Associated With cadm2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
Domain	IPR003585	Neurexin/syndecan/glycophorin C
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR013106	Immunoglobulin V-set domain
Domain	IPR013162	CD80-like, immunoglobulin C2-set
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	CD80-like, immunoglobulin C2-set	Immunoglobulin domain subtype	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin/major histocompatibility complex, conserved site	Immunoglobulin subtype 2	Immunoglobulin V-set domain	Neurexin/syndecan/glycophorin C
UniProtKB:A0A8M9PTN6 InterPro	436
UniProtKB:A0A8M9Q678 InterPro	433
UniProtKB:Q6PFK4 InterPro	405
UniProtKB:A0A8M2B1G4 InterPro	427
UniProtKB:A0A8M2B1M0 InterPro	442