Gene

spop

ID

ZDB-GENE-040426-1378

Name

speckle type BTB/POZ protein

Symbol

spop Nomenclature History

Previous Names

zgc:64140

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to localize to Cul3-RING ubiquitin ligase complex; cytoplasm; and nucleus. Orthologous to human SPOP (speckle type BTB/POZ protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64140 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Boysen et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With spop Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Nabais Sa-de Vries syndrome, type 1	618828
		Nabais Sa-de Vries syndrome, type 2	618829

Associated With spop Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000210	BTB/POZ domain
Domain	IPR002083	MATH/TRAF domain
Domain	IPR034089	SPOP, C-terminal BACK domain
Homologous_superfamily	IPR008974	TRAF-like
Homologous_superfamily	IPR011333	SKP1/BTB/POZ domain superfamily

Domain Details Per Protein

Protein	Length	BTB/POZ domain	MATH/TRAF domain	SKP1/BTB/POZ domain superfamily	SPOP, C-terminal BACK domain	TRAF-like
UniProtKB:Q7T330 InterPro	374
UniProtKB:A7YYH8 InterPro	374

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	spop-201 (1) Ensembl	Ensembl	2,394 nt	Select Tool ZFIN BLAST
mRNA	spop-202 (1) Ensembl	Ensembl	2,448 nt	Select Tool
mRNA	spop-204 (1) Ensembl	Ensembl	2,222 nt	Select Tool ZFIN BLAST
ncRNA	spop-002 (1) Ensembl	Ensembl	535 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations